Figure 7.

Structural consequences of DICER1 Platform variants. (A) Overview location of pathogenic variants (yellow) on Platform/PAZ crystal structure with hydrophobic residues in red and hydrophilic residues in blue (Tian et al., 2014) (PDB: 4NH3). (B) Consequences of side chain substitution for the specific variants found in the hydrophobic core using the PyMol Wizard mutagenesis script. Clashes are depicted by red plates that represent van der Waals interactions. Other residues proximal to the clashes are listed in the panel.