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DICER1 tumor predisposition syndrome (DTPS) tumorigenesis. (A) Schematic of genetic events seen with classical tumor suppressor genes, for example RB1, during tumorigenesis. (B) Schematic of usual DICER1 genetic events required for tumorigenesis in persons with DTPS. (C) Schematic of DICER1 genetic events required for tumorigenesis in persons with germline Platform missense variants.
