. 2023 May 30;145(23):12532–12540. doi: 10.1021/jacs.3c00744

Table 1. Optimization of the Reaction Conditions^a.

Reactions were carried out with vinyl amide (0.2 mmol), aryl iodide (0.1 mmol), PhSO₂Na (0.2 mmol), L·NiBr₂ (10 mol %), 4-CzIPN (1 mol %), additive (0.9 mmol), solvent [0.05 M], 34 W blue LED, 0 °C, 18 h. Isolated yields after column chromatography. Enantiomeric ratios (er) were determined by HPLC with a chiral stationary phase.

–20 °C.

DME [0.025 M].

Vinyl amide/aryl iodide/PhSO₂Na = 2/1/2, 390 nm 45 W Kessil LED, 48 h.

No nickel, no PC, or no light. DME: dimethoxyethane. ND: not detected.

Table 1. Optimization of the Reaction Conditionsa.

Table 1. Optimization of the Reaction Conditions^a.