Table 6.

Excess relative risk estimates for all solid cancer incidence by calendar period or age at exposure under linear-quadratic dose-response model: LSS, 1958–2009

Calendar period				Age at bombing
Year	Cases	Q/L	P a	Year	Cases	Q/L	P a
		95% CI				95% CI
Males				Males
1958–1987	4,878	2.34b	0.031	20–83	5,628	0.16	0.891
		≤−1.25 or ≥0.12				Undefined
1988–2009	5,595	1.52	0.022	0–19	4,845	2.43	<0.001
		≤−3.16 or ≥0.13				≤−3.23 or ≥0.33
Pc		0.845				0.258
Females				Females
1958–1987	6,053	0.04	0.850	20–83	8,220	−0.02	0.573
		−0.14 to 0.40				−0.21 to 0.41
1988–2009	6,012	0.23	0.373	0–19	3,845	0.20	0.273
		−0.07 to 1.06				−0.05 to 0.75
Pc		0.388				0.294

Note. LSS, Life Span Study. ERR, excess relative risk. L, linear dose coefficient. Q, quadratic dose coefficient. Q/L, ratio of quadratic to linear dose coefficient or curvature. 95% CI, confidence interval.

^aP value for quadratic departure from linearity.

^bCurvature estimates are from linear-quadratic ERR models with parametric background (common to both calendar periods or ages at exposure), multiplicative adjustment for smoking, independent effect modification by sex, sex-specific attained age, age at exposure, and high dose.

^cP value for heterogeneity in sex-specific curvature by calendar period or age at exposure.