Table 2.
Overall Numbers and Percentage of Pooled Numbers for Hospitalization and Totals
| Study | Total CCP Outcomes |
Total CCP | Total Control Outcomes | Total Control | Totals | CCP, % | Control, % | ARR, % (95% CI) | RRR % (95% CI) | Significance Level, P Value | NNT Benefit |
|---|---|---|---|---|---|---|---|---|---|---|---|
| mITT (all-cause hospitalizations) | 111 | 1305 | 160 | 1315 | 2620 | 8.5 | 12.2 | 3.7 (1.3–6.0) | 30.1 (12.0–44.4) | .0011 | 27 |
| mITT (hospitalizations after 24 h from transfusion) | 88 | 1282 | 147 | 1302 | 2584 | 6.9 | 11.3 | 4.4 (2.2–6.6) | 39.2 (21.7–52.8) | .0001 | 23 |
| Onset ≤5 d | 70 | 787 | 114 | 775 | 1562 | 8.9 | 14.7 | 5.8 (2.6–9.0) | 39.5 (19.9–54.3) | .0002 | 17 |
| Onset ≥6 d | 41 | 518 | 46 | 540 | 1058 | 7.9 | 8.5 | .6 (−2.7 to 3.9) | 7.1 (−39.1 to 37.9) | .3605 | 166 |
| Donor titer ≥ median | 49 | 687 | 157 | 1315 | 2002 | 7.1 | 11.9 | 4.8 (2.2–7.4) | 40.3 (18.8–56.1) | .0004 | 21 |
| Donor titer below median | 62 | 593 | 157 | 1315 | 1908 | 10.5 | 11.9 | 1.5 (−1.5 to 4.5) | 12.4 (−15.6 to 33.7) | .1735 | 67 |
| High titer AND onset ≤5 d | 29 | 406 | 114 | 775 | 1181 | 7.1 | 14.7 | 7.6 (4.0–11.1) | 51.4 (28.3–67.1) | .0001 | 13 |
| Low titer and onset ≤5 d, high titer and onset >5 d, low titer and onset >5 d | 75 | 836 | 160 | 1315 | 2151 | 9.0 | 12.2 | 3.2 (.6–5.8) | 26.3 (4.4–43.2) | .0105 | 31 |
Data are presented as No. unless otherwise indicated.
Abbreviations: ARR, absolute risk reduction; CCP, coronavirus disease 2019 convalescent plasma; CI, confidence interval; mITT, modified intention-to-treat; NNT, number needed to treat; RRR, relative risk reduction.