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. 2023 Jul 1;32(7):e4686. doi: 10.1002/pro.4686

FIGURE 2.

FIGURE 2

Therapeutic strategies for protein aggregation diseases. The four current strategies for targeting aggregating proteins are through (1) overall protein reduction, (2) inhibiting aggregation using small molecules or chaperones to block protein interactions or stabilizing the native form, (3) breaking down formed aggregates using antibodies or disaggregases, or (4) preventing toxic interactions by blocking the interaction or promoting non‐toxic aggregates.