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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Environ Res. 2023 Mar 31;228:115769. doi: 10.1016/j.envres.2023.115769

Table 2:

Additive (RERIa) and Multiplicative (RORb) Interactions between Single-Nucleotide Polymorphisms and Parental Occupational Solvent Exposures and the Risk of Autism Spectrum Disorders.

CHRc GENE SNPsd Minor allele MAF RERI 95% LLe 95% ULf P value FDRg RERI ROR 95% LL 95% UL P value FDR ROR
6 ALDH5A1 rs3765311 G 0.48 0.62 0.17 1.06 0.0071 0.0154 2.13 1.05 4.33 0.0366 0.0401
7 CNTNAP2 rs11771882 T 0.04 −2.70 −5.77 0.37 0.0848 0.0937 0.17 0.04 0.64 0.0092 0.0147
rs12703756 G 0.05 1.44 0.00 2.88 0.0508 0.0614 4.40 1.46 13.23 0.0083 0.0147
rs700316 A 0.21 0.86 0.30 1.41 0.0024 0.0089 2.69 1.38 5.21 0.0035 0.0140
rs75454072 T 0.07 −1.95 −3.86 −0.05 0.0444 0.0542 0.27 0.11 0.70 0.0067 0.0145
4 EGF rs11569014 A 0.02 9.27 −10.97 29.50 0.3695 0.3695 23.07 2.29 232.53 0.0078 0.0146
rs2298991 G 0.47 0.59 0.15 1.03 0.0092 0.0169 2.08 1.03 4.17 0.0400 0.0427
rs6533489 G 0.43 0.69 0.30 1.08 0.0005 0.0031 2.47 1.27 4.80 0.0075 0.0145
rs6845765 T 0.26 0.79 0.28 1.31 0.0025 0.0089 2.40 1.27 4.53 0.0067 0.0145
rs9030 G 0.36 0.71 0.25 1.17 0.0026 0.0089 2.27 1.20 4.31 0.0119 0.0177
rs9990430 T 0.41 0.74 0.35 1.13 0.0002 0.0015 2.64 1.37 5.09 0.0037 0.0140
6 GABBR1 rs28359976 G 0.10 0.88 0.14 1.63 0.0201 0.0307 2.99 1.30 6.85 0.0097 0.0148
rs29262 G 0.09 0.90 0.13 1.67 0.0214 0.0319 3.07 1.32 7.13 0.0091 0.0147
rs3025626 A 0.10 0.90 0.14 1.67 0.0204 0.0307 3.06 1.32 7.06 0.0088 0.0147
10 GLRX3 rs650161 A 0.40 0.62 0.27 0.97 0.0005 0.0031 2.44 1.25 4.74 0.0088 0.0147
rs7085125 C 0.38 0.63 0.20 1.05 0.0041 0.0112 2.17 1.13 4.15 0.0202 0.0254
rs7904125 C 0.43 0.68 0.18 1.19 0.0081 0.0160 2.13 1.07 4.25 0.0314 0.0361
6 HCP5 rs3094604 G 0.14 −1.22 −2.34 −0.09 0.0345 0.0449 0.38 0.19 0.79 0.0096 0.0148
6 HLA-C * HLA-B rs2442727 A 0.12 −1.13 −2.14 −0.13 0.0266 0.0385 0.35 0.17 0.73 0.0054 0.0140
rs2524067 G 0.15 −1.12 −2.11 −0.14 0.0253 0.0371 0.36 0.18 0.74 0.0050 0.0140
rs4469339 A 0.41 0.64 0.23 1.05 0.0022 0.0089 2.29 1.16 4.49 0.0165 0.0217
rs4992474 T 0.35 −1.36 −2.58 −0.14 0.0283 0.0400 0.38 0.20 0.71 0.0028 0.0134
rs73728881 C 0.35 −1.17 −2.29 −0.05 0.0415 0.0512 0.42 0.22 0.79 0.0073 0.0145
6 HLA-F rs3116807 A 0.44 −1.27 −2.58 0.05 0.0589 0.0677 0.41 0.21 0.81 0.0098 0.0148
5 HTR1A rs1402912 A 0.25 0.72 0.26 1.17 0.0021 0.0089 2.39 1.26 4.53 0.0074 0.0145
rs173689 T 0.49 0.66 0.20 1.13 0.0052 0.0131 2.22 1.07 4.62 0.0323 0.0364
rs347664 G 0.47 0.71 0.25 1.18 0.0025 0.0089 2.33 1.13 4.78 0.0215 0.0269
rs6861297 G 0.10 −1.42 −2.72 −0.12 0.0319 0.0436 0.31 0.14 0.71 0.0057 0.0140
rs72758792 G 0.19 −1.26 −2.31 −0.21 0.0185 0.0293 0.35 0.18 0.69 0.0023 0.0128
6 HTR1B rs10943542 T 0.14 0.97 0.28 1.66 0.0056 0.0136 3.09 1.47 6.49 0.0029 0.0134
rs1335430 G 0.24 0.59 0.22 0.95 0.0017 0.0086 2.39 1.26 4.53 0.0075 0.0145
rs236852 A 0.50 0.60 0.21 1.00 0.0029 0.0096 2.24 1.08 4.65 0.0297 0.0352
rs3004002 A 0.41 0.81 0.47 1.16 0.0000 0.0001 3.17 1.61 6.24 0.0009 0.0128
rs4075570 G 0.37 0.72 0.24 1.20 0.0033 0.0105 2.25 1.17 4.33 0.0149 0.0208
rs4708281 G 0.31 0.49 0.12 0.87 0.0102 0.0175 1.99 1.05 3.77 0.0356 0.0393
rs58693007 T 0.20 0.70 0.24 1.15 0.0026 0.0089 2.53 1.30 4.92 0.0060 0.0142
rs62426461 G 0.13 0.85 0.23 1.47 0.0073 0.0155 2.85 1.35 6.00 0.0060 0.0142
rs62433374 A 0.39 0.70 0.33 1.06 0.0002 0.0015 2.57 1.33 4.96 0.0048 0.0140
rs75278569 G 0.16 0.94 0.39 1.49 0.0008 0.0046 3.37 1.66 6.85 0.0008 0.0128
rs7764654 C 0.38 0.60 0.15 1.06 0.0096 0.0169 2.04 1.06 3.90 0.0317 0.0361
rs7771755 T 0.48 0.59 0.15 1.02 0.0079 0.0159 2.11 1.02 4.39 0.0448 0.0460
rs77723474 C 0.03 2.28 −0.39 4.94 0.0938 0.0980 7.63 1.84 31.63 0.0051 0.0140
3 HTR1F rs114838037 G 0.02 4.32 −1.66 10.31 0.1568 0.1596 13.05 2.05 83.24 0.0066 0.0145
rs76107227 C 0.02 4.44 −2.62 11.49 0.2178 0.2197 16.31 2.31 115.28 0.0051 0.0140
13 HTR2A rs1172402 C 0.18 −1.16 −2.22 −0.09 0.0331 0.0436 0.38 0.19 0.77 0.0069 0.0145
rs1928045 C 0.46 0.59 0.17 1.01 0.0061 0.0144 2.11 1.05 4.22 0.0348 0.0389
rs2149436 C 0.42 0.67 0.24 1.09 0.0020 0.0089 2.31 1.17 4.55 0.0162 0.0216
rs4942590 C 0.34 0.68 0.22 1.14 0.0035 0.0108 2.23 1.18 4.22 0.0139 0.0199
rs6311 T 0.41 0.56 0.17 0.96 0.0053 0.0131 2.10 1.07 4.12 0.0315 0.0361
rs73193067 A 0.14 −1.59 −3.05 −0.13 0.0324 0.0436 0.35 0.16 0.73 0.0056 0.0140
rs9526307 A 0.50 0.61 0.16 1.05 0.0074 0.0155 2.15 1.04 4.47 0.0396 0.0427
5 HTR4 rs11956922 A 0.47 0.58 0.13 1.03 0.0115 0.0191 2.03 1.00 4.11 0.0498 0.0502
rs6580550 T 0.47 0.54 0.11 0.98 0.0143 0.0234
10 HTR7 rs1001064 G 0.38 0.75 0.34 1.17 0.0004 0.0030 2.56 1.33 4.90 0.0048 0.0140
rs1326843 G 0.20 0.80 0.29 1.31 0.0021 0.0089 2.61 1.34 5.06 0.0047 0.0140
rs17092874 C 0.15 −1.39 −2.57 −0.22 0.0197 0.0305 0.32 0.16 0.67 0.0022 0.0128
12 IFNG rs10784678 C 0.38 0.62 0.19 1.06 0.0052 0.0131 2.13 1.11 4.05 0.0220 0.0272
1 IL10 rs79707006 G 0.07 −1.69 −3.26 −0.12 0.0353 0.0450 0.24 0.09 0.62 0.0033 0.0140
3 IL12A rs12491474 G 0.07 −1.95 −3.73 −0.16 0.0323 0.0436 0.22 0.08 0.59 0.0028 0.0134
rs2647929 T 0.42 0.58 0.16 0.99 0.0064 0.0146 2.08 1.07 4.06 0.0315 0.0361
2 IL1B rs10169916 T 0.39 0.76 0.40 1.12 0.0000 0.0005 2.86 1.48 5.53 0.0017 0.0128
rs1143623 G 0.31 0.66 0.21 1.10 0.0039 0.0112 2.21 1.17 4.16 0.0142 0.0201
rs1143633 T 0.34 −1.38 −2.65 −0.11 0.0327 0.0436 0.40 0.21 0.75 0.0046 0.0140
rs115821385 A 0.06 −1.67 −3.37 0.03 0.0538 0.0631 0.23 0.08 0.64 0.0046 0.0140
rs11690539 A 0.35 0.78 0.40 1.17 0.0001 0.0008 2.81 1.49 5.33 0.0015 0.0128
rs16944 A 0.39 0.73 0.38 1.09 0.0001 0.0007 2.77 1.43 5.36 0.0026 0.0134
rs2466446 C 0.39 0.74 0.40 1.09 0.0000 0.0005 2.86 1.47 5.53 0.0019 0.0128
rs2723152 T 0.32 0.70 0.30 1.11 0.0007 0.0041 2.47 1.31 4.65 0.0052 0.0140
2 IL1RN rs17669228 T 0.18 −1.26 −2.37 −0.14 0.0270 0.0386 0.37 0.19 0.73 0.0044 0.0140
rs2592346 G 0.44 0.61 0.27 0.95 0.0005 0.0031 2.44 1.21 4.90 0.0125 0.0184
8 NAT1 rs1024363 T 0.27 0.71 0.19 1.24 0.0075 0.0155 2.19 1.16 4.14 0.0160 0.0215
rs60962775 T 0.10 −1.58 −3.19 0.02 0.0532 0.0629 0.32 0.14 0.76 0.0090 0.0147
rs6586711 C 0.31 0.66 0.20 1.12 0.0046 0.0121 2.19 1.16 4.13 0.0156 0.0214
8 NAT2 rs6998188 C 0.49 0.62 0.16 1.09 0.0085 0.0165 2.12 1.03 4.34 0.0408 0.0431
7 PON1 rs1157745 T 0.38 0.80 0.47 1.14 0.0000 0.0001 3.20 1.66 6.18 0.0005 0.0128
rs2074351 A 0.30 0.83 0.41 1.26 0.0001 0.0011 2.82 1.49 5.31 0.0014 0.0128
rs2237580 G 0.13 1.01 0.34 1.67 0.0031 0.0100 3.14 1.50 6.57 0.0023 0.0128
rs2299256 A 0.27 0.85 0.45 1.26 0.0000 0.0006 3.11 1.63 5.93 0.0006 0.0128
rs2299257 C 0.44 0.83 0.46 1.20 0.0000 0.0003 3.12 1.56 6.24 0.0012 0.0128
rs35339934 A 0.13 0.71 0.25 1.18 0.0025 0.0089 3.00 1.43 6.28 0.0035 0.0140
rs3917498 T 0.41 0.81 0.45 1.18 0.0000 0.0003 3.07 1.54 6.11 0.0014 0.0128
rs3917577 C 0.13 0.99 0.32 1.67 0.0040 0.0112 3.03 1.45 6.31 0.0031 0.0140
rs662 C 0.38 0.81 0.48 1.14 0.0000 0.0001 3.24 1.68 6.26 0.0004 0.0128
rs854555 A 0.39 0.61 0.22 0.99 0.0021 0.0089 2.23 1.16 4.31 0.0166 0.0217
6 PSMB9 rs10214759 T 0.03 1.77 −0.11 3.65 0.0652 0.0741 8.47 1.80 39.80 0.0068 0.0145
rs17220241 T 0.03 2.05 −0.32 4.43 0.0897 0.0973 8.64 1.73 43.26 0.0087 0.0147
rs56672687 T 0.03 1.96 −0.14 4.06 0.0669 0.0753 8.32 1.75 39.58 0.0078 0.0146
rs73412927 A 0.03 1.88 −0.14 3.90 0.0683 0.0761 7.99 1.68 37.96 0.0090 0.0147
7 RELN rs34566446 G 0.46 0.54 0.13 0.94 0.0089 0.0169 2.05 1.02 4.12 0.0447 0.0460
rs56041591 T 0.06 2.90 −0.60 6.40 0.1046 0.1084 5.52 1.68 18.13 0.0049 0.0140
rs671372 T 0.46 0.61 0.27 0.95 0.0005 0.0031 2.47 1.21 5.05 0.0129 0.0187
rs6954835 G 0.47 0.56 0.18 0.94 0.0038 0.0112 2.21 1.04 4.73 0.0401 0.0427
15 RORA rs1523526 C 0.48 0.53 0.14 0.92 0.0077 0.0156 2.09 1.02 4.29 0.0452 0.0460
rs16944364 G 0.08 1.18 0.29 2.07 0.0096 0.0169 4.00 1.65 9.73 0.0022 0.0128
rs2143 A 0.50 −2.05 −3.99 −0.12 0.0377 0.0473 0.28 0.13 0.60 0.0010 0.0128
rs2414708 G 0.24 −1.25 −2.37 −0.12 0.0297 0.0415 0.40 0.21 0.77 0.0055 0.0140
rs4775287 C 0.34 0.60 0.15 1.05 0.0094 0.0169 2.03 1.07 3.85 0.0297 0.0352
rs58306294 T 0.25 0.69 0.17 1.22 0.0093 0.0169 2.14 1.13 4.06 0.0197 0.0252
rs67288758 G 0.05 −2.17 −4.40 0.06 0.0568 0.0659 0.14 0.04 0.46 0.0011 0.0128
rs7168305 A 0.08 1.03 0.24 1.82 0.0107 0.0180 4.22 1.67 10.68 0.0023 0.0128
rs72750685 T 0.05 −2.06 −4.46 0.34 0.0929 0.0980 0.21 0.07 0.68 0.0092 0.0147
rs75885569 T 0.03 2.11 −0.61 4.84 0.1287 0.1322 8.14 1.72 38.63 0.0083 0.0147
rs75941956 C 0.04 2.46 −0.36 5.28 0.0870 0.0952 7.62 1.90 30.54 0.0041 0.0140
6 SOD2 rs117664822 A 0.04 −1.99 −4.31 0.32 0.0912 0.0980 0.17 0.05 0.64 0.0083 0.0147
rs4632918 A 0.34 −1.22 −2.37 −0.07 0.0380 0.0473 0.42 0.22 0.79 0.0074 0.0145
rs6919792 G 0.33 0.64 0.20 1.08 0.0046 0.0121 2.16 1.15 4.07 0.0173 0.0224
7 ST7 * WNT2 rs38911 A 0.46 0.68 0.34 1.02 0.0001 0.0011 2.67 1.32 5.38 0.0061 0.0142
6 TAP1 * PSMB9 rs17213826 T 0.04 1.51 −0.02 3.03 0.0524 0.0627 5.90 1.53 22.66 0.0098 0.0148
6 TAP2 rs3819721 A 0.24 0.60 0.17 1.02 0.0062 0.0144 2.20 1.16 4.19 0.0157 0.0214
rs73410785 C 0.03 2.63 −0.44 5.69 0.0933 0.0980 14.01 2.77 70.82 0.0014 0.0128
1 TGFB2 rs12119526 T 0.14 −1.42 −2.61 −0.24 0.0188 0.0295 0.32 0.15 0.66 0.0020 0.0128
rs1473527 A 0.36 0.58 0.16 1.00 0.0071 0.0154 2.06 1.08 3.93 0.0283 0.0342
rs41313742 T 0.07 1.80 0.13 3.47 0.0348 0.0449 4.05 1.53 10.72 0.0048 0.0140
rs682483 A 0.48 0.54 0.13 0.95 0.0100 0.0174 2.03 1.02 4.06 0.0450 0.0460
rs878394 A 0.48 0.61 0.24 0.99 0.0015 0.0077 2.34 1.12 4.86 0.0229 0.0279
6 VEGFA rs62401175 G 0.16 −1.97 −3.57 −0.36 0.0161 0.0260 0.29 0.14 0.60 0.0008 0.0128
a.

RERI = relative excess risk for interaction

b.

ROR= ratio odds ratio

c.

CHR-= chromosome

d.

SNPs=single nucleotide polymorphisms

e.

95% LL – 95% confidence interval lower limit

f.

95% UL = 95% confidence interval upper limit

g.

FDR= false discovery rate corrected p-value