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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Environ Res. 2023 Mar 31;228:115769. doi: 10.1016/j.envres.2023.115769

Table 3:

Odds ratios associated with gene only, solvents only, and gene – solvent and ASD

CHRa GENE SNPsb Minor allele Solvent Only 95% LLc 95% ULd p-value SNPe Only 95% LL 95% UL p-value Solvent * SNP 95% LL 95% UL p-value
6 ALDH5A1 rs3765311 G 0.60 0.33 1.11 0.102 0.77 0.46 1.28 0.315 0.99 0.59 1.65 0.964
7 CNTNAP2 rs11771882 T 1.19 0.85 1.66 0.314 3.14 1.22 8.08 0.018 0.63 0.24 1.64 0.341
rs12703756 G 0.89 0.63 1.25 0.489 0.46 0.22 0.95 0.037 1.78 0.79 4.02 0.167
rs700316 A 0.71 0.48 1.07 0.099 0.62 0.39 1.00 0.048 1.19 0.73 1.96 0.484
rs75454072 T 1.26 0.89 1.78 0.197 2.59 1.31 5.13 0.006 0.89 0.47 1.70 0.726
4 EGF rs11569014 A 0.94 0.67 1.30 0.694 0.45 0.17 1.17 0.102 9.65 1.18 78.84 0.034
rs2298991 G 0.62 0.35 1.12 0.114 0.72 0.44 1.19 0.204 0.94 0.58 1.53 0.803
rs6533489 G 0.57 0.34 0.98 0.043 0.64 0.40 1.03 0.065 0.90 0.56 1.45 0.679
rs6845765 T 0.69 0.45 1.07 0.098 0.73 0.46 1.16 0.181 1.22 0.78 1.91 0.388
rs9030 G 0.64 0.39 1.06 0.081 0.76 0.48 1.20 0.233 1.11 0.70 1.76 0.667
rs9990430 T 0.56 0.33 0.95 0.030 0.63 0.39 1.02 0.058 0.94 0.59 1.50 0.785
6 GABBR1 rs28359976 G 0.83 0.58 1.19 0.306 0.48 0.28 0.84 0.010 1.20 0.64 2.23 0.575
rs29262 G 0.84 0.59 1.20 0.329 0.47 0.27 0.82 0.009 1.21 0.64 2.29 0.559
rs3025626 A 0.83 0.58 1.18 0.297 0.48 0.27 0.84 0.010 1.21 0.64 2.28 0.556
10 GLRX3 rs650161 A 0.58 0.34 0.99 0.047 0.49 0.30 0.80 0.005 0.70 0.43 1.13 0.142
rs7085125 C 0.66 0.39 1.09 0.106 0.67 0.42 1.09 0.106 0.96 0.59 1.55 0.855
rs7904125 C 0.62 0.35 1.10 0.103 0.94 0.58 1.54 0.816 1.24 0.76 2.02 0.386
6 HCP5 rs3094604 G 1.34 0.92 1.95 0.123 1.81 1.08 3.03 0.025 0.93 0.55 1.57 0.792
6 rs2442727 A 1.33 0.92 1.93 0.132 1.49 0.88 2.54 0.137 0.69 0.40 1.18 0.177
rs2524067 G 1.34 0.92 1.96 0.129 1.53 0.92 2.52 0.100 0.74 0.45 1.24 0.254
HLA-C * rs4469339 A 0.60 0.34 1.03 0.064 0.66 0.40 1.07 0.094 0.90 0.56 1.45 0.660
HLA-B rs4992474 T 1.82 1.11 3.00 0.018 1.71 1.06 2.73 0.027 1.17 0.73 1.87 0.521
rs73728881 C 1.72 1.05 2.82 0.032 1.58 0.99 2.53 0.055 1.13 0.71 1.81 0.601
6 HLA-F rs3116807 A 1.92 1.08 3.40 0.026 1.58 0.96 2.59 0.069 1.23 0.76 2.01 0.396
rs1402912 A 0.71 0.46 1.08 0.111 0.61 0.39 0.98 0.041 1.04 0.66 1.63 0.878
rs173689 T 0.57 0.30 1.08 0.084 0.86 0.50 1.48 0.594 1.10 0.64 1.88 0.728
5 HTR1A rs347664 G 0.57 0.31 1.06 0.077 0.87 0.50 1.50 0.615 1.15 0.66 2.02 0.614
rs6861297 G 1.28 0.90 1.84 0.170 1.89 1.04 3.44 0.036 0.76 0.42 1.35 0.343
rs72758792 G 1.45 0.98 2.15 0.063 1.64 0.99 2.69 0.052 0.83 0.52 1.33 0.434
rs10943542 T 0.77 0.53 1.12 0.172 0.54 0.32 0.89 0.016 1.28 0.73 2.24 0.396
rs1335430 G 0.70 0.46 1.09 0.113 0.42 0.27 0.68 0.000 0.71 0.45 1.13 0.147
rs236852 A 0.57 0.30 1.07 0.080 0.62 0.36 1.08 0.095 0.80 0.46 1.39 0.42
rs3004002 A 0.48 0.28 0.83 0.009 0.57 0.34 0.93 0.026 0.86 0.52 1.42 0.550
6 HTR1B rs4075570 G 0.63 0.38 1.05 0.078 0.83 0.52 1.34 0.444 1.18 0.73 1.90 0.503
rs4708281 G 0.68 0.42 1.11 0.122 0.50 0.31 0.80 0.004 0.67 0.41 1.10 0.112
rs58693007 T 0.73 0.49 1.10 0.131 0.50 0.31 0.81 0.005 0.94 0.58 1.51 0.788
rs62426461 G 0.78 0.54 1.13 0.183 0.52 0.31 0.87 0.013 1.15 0.66 1.99 0.631
rs62433374 A 0.56 0.33 0.96 0.034 0.58 0.36 0.94 0.028 0.84 0.52 1.37 0.485
rs75278569 G 0.73 0.50 1.07 0.102 0.46 0.28 0.77 0.003 1.13 0.68 1.88 0.642
rs7764654 C 0.66 0.40 1.10 0.114 0.76 0.47 1.22 0.248 1.02 0.63 1.65 0.932
rs7771755 T 0.60 0.32 1.12 0.11 0.71 0.41 1.22 0.213 0.89 0.52 1.54 0.687
rs77723474 C 0.91 0.65 1.27 0.583 0.37 0.14 0.97 0.043 2.56 0.89 7.33 0.080
3 HTR1F rs114838037 G 0.93 0.67 1.29 0.660 0.38 0.10 1.43 0.154 4.63 1.27 16.95 0.021
rs76107227 C 0.93 0.67 1.29 0.656 0.31 0.09 1.07 0.063 4.67 1.03 21.27 0.046
rs1172402 C 1.36 0.92 2.00 0.122 1.68 1.00 2.82 0.051 0.88 0.55 1.39 0.577
rs1928045 C 0.61 0.34 1.09 0.094 0.71 0.42 1.18 0.187 0.90 0.54 1.51 0.699
rs2149436 C 0.57 0.33 1.01 0.053 0.75 0.45 1.23 0.252 0.98 0.59 1.63 0.947
13 HTR2A rs4942590 C 0.66 0.41 1.06 0.086 0.73 0.46 1.17 0.189 1.07 0.68 1.71 0.762
rs6311 T 0.62 0.35 1.09 0.096 0.61 0.37 1.02 0.057 0.80 0.48 1.33 0.383
rs73193067 A 1.34 0.92 1.95 0.124 2.34 1.34 4.09 0.003 1.09 0.65 1.82 0.755
rs9526307 A 0.58 0.31 1.08 0.088 0.77 0.45 1.29 0.316 0.95 0.57 1.60 0.851
5 HTR4 rs11956922 A 0.62 0.34 1.14 0.124 0.78 0.46 1.32 0.356 0.98 0.58 1.67 0.950
rs6580550 T 0.60 0.32 1.11 0.103 0.72 0.42 1.22 0.222 0.85 0.50 1.46 0.564
rs1001064 G 0.58 0.35 0.97 0.039 0.68 0.42 1.10 0.121 1.02 0.64 1.64 0.93
10 HTR7 rs1326843 G 0.73 0.49 1.09 0.123 0.59 0.36 0.95 0.032 1.12 0.70 1.79 0.640
rs17092874 C 1.41 0.96 2.05 0.078 1.80 1.05 3.09 0.032 0.81 0.50 1.32 0.408
12 IFNG rs10784678 C 0.66 0.40 1.09 0.103 0.71 0.44 1.13 0.151 0.99 0.63 1.57 0.968
1 IL10 rs79707006 G 1.24 0.88 1.75 0.220 2.06 1.02 4.15 0.043 0.61 0.32 1.18 0.144
3 IL12A rs12491474 G 1.25 0.89 1.77 0.199 2.34 1.16 4.73 0.018 0.65 0.32 1.31 0.228
rs2647929 T 0.63 0.36 1.09 0.098 0.67 0.41 1.08 0.103 0.87 0.54 1.41 0.582
rs10169916 T 0.55 0.33 0.93 0.025 0.54 0.33 0.88 0.014 0.85 0.52 1.39 0.526
rs1143623 G 0.69 0.43 1.09 0.109 0.67 0.42 1.06 0.088 1.01 0.63 1.62 0.963
rs1143633 T 1.75 1.08 2.83 0.023 2.07 1.30 3.31 0.002 1.44 0.90 2.30 0.125
2 IL1B rs115821385 A 1.26 0.89 1.79 0.192 1.99 0.90 4.39 0.091 0.58 0.31 1.09 0.089
rs11690539 A 0.58 0.36 0.94 0.026 0.58 0.36 0.92 0.022 0.94 0.59 1.51 0.798
rs16944 A 0.54 0.32 0.92 0.023 0.55 0.34 0.90 0.018 0.83 0.51 1.36 0.456
rs2466446 C 0.53 0.31 0.89 0.017 0.54 0.33 0.88 0.013 0.80 0.49 1.32 0.386
rs2723152 T 0.64 0.40 1.02 0.060 0.59 0.37 0.95 0.028 0.94 0.58 1.50 0.789
2 IL1RN rs17669228 T 1.41 0.95 2.09 0.084 1.76 1.05 2.96 0.033 0.92 0.58 1.44 0.708
rs2592346 G 0.55 0.30 0.99 0.046 0.46 0.27 0.78 0.004 0.62 0.37 1.05 0.074
rs1024363 T 0.73 0.48 1.12 0.151 0.74 0.47 1.17 0.201 1.19 0.75 1.87 0.458
8 NAT1 rs60962775 T 1.26 0.88 1.80 0.207 2.24 1.15 4.34 0.017 0.91 0.54 1.55 0.74
rs6586711 C 0.68 0.43 1.08 0.100 0.70 0.44 1.10 0.122 1.04 0.66 1.63 0.871
8 NAT2 rs6998188 C 0.60 0.33 1.12 0.110 0.82 0.49 1.37 0.445 1.05 0.63 1.74 0.861
7 PON1 rs1157745 T 0.50 0.29 0.84 0.009 0.51 0.32 0.82 0.005 0.81 0.51 1.29 0.377
rs2074351 A 0.58 0.37 0.93 0.025 0.65 0.41 1.03 0.064 1.07 0.69 1.66 0.773
rs2237580 G 0.78 0.54 1.13 0.183 0.54 0.32 0.93 0.025 1.33 0.79 2.23 0.288
rs2299256 A 0.63 0.40 0.99 0.044 0.51 0.32 0.81 0.005 0.99 0.63 1.56 0.96
rs2299257 C 0.46 0.26 0.83 0.009 0.67 0.41 1.09 0.106 0.96 0.59 1.56 0.867
rs35339934 A 0.78 0.54 1.14 0.199 0.56 0.33 0.96 0.034 1.15 0.66 2.02 0.614
rs3917498 T 0.48 0.27 0.86 0.013 0.61 0.37 1.00 0.049 0.91 0.56 1.47 0.692
rs3917577 C 0.78 0.54 1.13 0.196 0.57 0.33 0.96 0.035 1.34 0.80 2.25 0.273
rs662 C 0.50 0.29 0.84 0.009 0.50 0.31 0.81 0.004 0.81 0.51 1.29 0.377
rs854555 A 0.61 0.36 1.04 0.069 0.59 0.37 0.96 0.032 0.81 0.51 1.29 0.379
rs10214759 T 0.93 0.67 1.30 0.672 0.25 0.07 0.83 0.023 1.95 0.73 5.16 0.181
6 PSMB9 rs17220241 T 0.95 0.68 1.31 0.736 0.28 0.08 0.95 0.041 2.28 0.80 6.51 0.124
rs56672687 T 0.94 0.68 1.31 0.716 0.28 0.08 0.95 0.041 2.18 0.83 5.75 0.115
rs73412927 A 0.94 0.68 1.31 0.718 0.28 0.08 0.95 0.042 2.10 0.80 5.54 0.133
rs34566446 G 0.62 0.34 1.13 0.117 0.58 0.34 0.98 0.040 0.74 0.43 1.24 0.251
7 RELN rs56041591 T 0.89 0.64 1.26 0.521 0.71 0.38 1.34 0.287 3.50 1.27 9.64 0.015
rs671372 T 0.54 0.29 0.99 0.047 0.44 0.26 0.75 0.003 0.59 0.35 1.00 0.052
rs6954835 G 0.54 0.28 1.05 0.07 0.51 0.28 0.92 0.024 0.61 0.34 1.10 0.103
rs1523526 C 0.60 0.32 1.12 0.107 0.51 0.30 0.89 0.017 0.64 0.37 1.11 0.11
rs16944364 G 0.84 0.59 1.19 0.326 0.43 0.23 0.82 0.010 1.45 0.77 2.73 0.244
15 RORA rs2143 A 2.68 1.39 5.18 0.003 1.55 0.94 2.58 0.089 1.18 0.72 1.95 0.51
rs2414708 G 1.59 1.03 2.45 0.036 1.82 1.14 2.92 0.013 1.17 0.74 1.84 0.505
rs4775287 C 0.68 0.42 1.11 0.127 0.73 0.46 1.16 0.189 1.02 0.64 1.61 0.942
rs58306294 T 0.74 0.48 1.14 0.169 0.75 0.47 1.18 0.211 1.18 0.74 1.86 0.486
rs67288758 G 1.23 0.88 1.72 0.228 2.35 0.95 5.82 0.064 0.42 0.20 0.87 0.02
rs7168305 A 0.84 0.59 1.19 0.321 0.34 0.18 0.66 0.001 1.21 0.62 2.35 0.573
rs72750685 T 1.18 0.84 1.65 0.338 2.50 1.00 6.29 0.051 0.63 0.30 1.29 0.202
rs75885569 T 0.92 0.66 1.28 0.626 0.31 0.11 0.88 0.029 2.35 0.73 7.56 0.153
rs75941956 C 0.91 0.65 1.27 0.591 0.40 0.15 1.03 0.057 2.77 0.99 7.74 0.052
6 SOD2 rs117664822 A 1.17 0.84 1.63 0.356 2.29 0.87 6.03 0.094 0.47 0.19 1.12 0.087
rs4632918 A 1.63 1.01 2.63 0.044 1.83 1.15 2.91 0.011 1.24 0.80 1.92 0.329
rs6919792 G 0.68 0.42 1.09 0.109 0.68 0.43 1.09 0.11 1.00 0.62 1.61 0.991
7 ST7 *
WNT2		 rs38911 A 0.52 0.28 0.93 0.029 0.52 0.31 0.87 0.013 0.72 0.43 1.20 0.205
6 TAP1 *
PSMB9		 rs17213826 T 0.93 0.67 1.30 0.674 0.32 0.11 0.90 0.030 1.76 0.74 4.20 0.203
6 TAP2 rs3819721 A 0.74 0.49 1.13 0.163 0.53 0.33 0.84 0.008 0.87 0.54 1.38 0.552
rs73410785 C 0.92 0.66 1.28 0.606 0.21 0.07 0.69 0.010 2.76 0.90 8.48 0.077
1 TGFB2 rs12119526 T 1.38 0.95 2.00 0.091 1.86 1.08 3.19 0.0242
\		 0.81 0.49 1.34 0.416
rs1473527 A 0.67 0.40 1.11 0.116 0.67 0.41 1.07 0.094 0.91 0.56 1.47 0.708
rs41313742 T 0.86 0.61 1.21 0.388 0.67 0.35 1.28 0.225 2.33 1.12 4.84 0.024
rs682483 A 0.63 0.35 1.12 0.116 0.60 0.36 1.00 0.048 0.76 0.46 1.26 0.293
rs878394 A 0.54 0.29 1.02 0.056 0.58 0.33 1.01 0.055 0.73 0.42 1.28 0.275
6 VEGFA rs62401175 G 1.42 0.97 2.07 0.072 2.64 1.52 4.59 0.001 1.09 0.68 1.74 0.715
a.

CHR-= chromosome

b.

SNPs= single nucleotide polymorphisms

c.

95% LL – 95% confidence interval lower limit

d.

95% UL = 95% confidence interval upper limit