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. 2023 Jun 16;24:410. doi: 10.1186/s13063-023-07425-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Time schedule of enrolment, interventions and assessments. At baseline (T0), subjects will receive and sign informed consent, and general patient information will be collected. The MDS-UPDRS III will be used to comprehensively evaluate MS of PWP at T0 and T1. The PDQ-39 evaluates the quality of life of patients with PD (PWP) at 4 weeks, 12 weeks and 24 weeks after intervention. The NMSS allows quantitative evaluation of NMS of PD. The changes in brain plasticity in different periods before and after rehabilitation intervention (at T0 and T1) were determined by magnetic resonance imaging (fMRI) and electroencephalogram (EEG). The 6-min walk distance (6MWD), 10-m walk (10MT), TUG, BBS, FTSTS for balance and posture control, and walking ability will be evaluated at T0 and T1. Any AEs will be recorded during the research. Safety indices will also be tested at T0 and T1. AEs will be recorded during the research