Table 3.

Lead variants for ADRD or ALS associated with both disorders at a family-wise error rate of 5%. Odds ratios and p-values for AD (from Kunkle et al.) are also included as a sensitivity analysis. A1 = effect allele; A2 = non-effect allele; OR = odds ratio; PP_{shared/distinct} = posterior probability that the two disorders share the same causal variant/have two distinct causal variants at the locus according to colocalization analysis. For ADRD, odds ratios and p-values are from the full 788,989 participants where available (i.e., for ADRD lead variants) and from the 487,511 participants with genome-wide summary statistics otherwise (i.e., for the ALS lead variant)

Locus	Variant	A1/A2	Lead for	AD		ADRD		ALS		PPshared	PPdistinct	Nearest gene	Most evidence for
				OR	p-value	OR	p-value	OR	p-value
1	rs871269	T/C	ADRD	0.97	0.068	0.96	8.7 × 10−9	0.95	6.8 × 10−6	0.9%	30.1%	TNIP1	GPX3
2	rs785129	T/C	ADRD	1.04	0.017	1.04	2.4 × 10−9	1.05	4.3 × 10−5	12.0%	84.0%	HS3ST5	HS3ST5, HDAC2, MARCKS
3	rs199515	C/G	ADRD	1.05	0.011	1.06	9.3 × 10−13	1.05	1.2 × 10−4	26.0%	63.9%	WNT3	MAPT, KANSL1
4	rs2526377	A/G	ADRD	1.07	2.0 × 10−6	1.05	1.6 × 10−12	1.04	1.0 × 10−4	73.9%	5.9%	TSPOAP1	TSPOAP1