Table 2.
Allelic and genotype TLR7 and MyD88 gene frequencies in the study population.
| Frequencies (%) |
Pa | HWEb | |||||
|---|---|---|---|---|---|---|---|
| Total (n = 618) |
Mild (n = 135) |
Severe (n = 208) |
Critical (N = 162) |
Deceased (n = 113) |
|||
| TLR7 | |||||||
| rs179008 | |||||||
| A | 965 (78%) | 199 (74%) | 328 (79%) | 254 (78%) | 184 (81%) | 0.20 | |
| T | 271 (22%) | 71 (26%) | 88 (21%) | 70 (22%) | 42 (19%) | ||
| AA | 451 (73%) | 89 (66%) | 156 (75%) | 117 (72%) | 89 (78%) | 0.10 | 0.07c |
| AT | 63 (10%) | 21 (15%) | 16 (8%) | 20 (12%) | 6 (5%) | ||
| TT | 104 (17%) | 25 (18%) | 36 (17%) | 25 (15%) | 18 (16%) | ||
| rs179009 | |||||||
| A | 743 (60%) | 148 (55%) | 253 (61%) | 205 (63%) | 137 (61%) | 0.20 | |
| G | 493 (40%) | 122 (45%) | 163 (39%) | 119 (37%) | 89 (39%) | ||
| AA | 319 (52%) | 56 (41%) | 109 (52%) | 92 (57%) | 62 (55%) | 0.02 | 0.6c |
| AG | 105 (17%) | 36 (27%) | 35 (17%) | 21 (13%) | 13 (11%) | ||
| GG | 194 (31%) | 43 (32%) | 64 (31%) | 49 (30%) | 38 (34%) | ||
| rs3853839 | |||||||
| C | 793 (65%) | 158 (59%) | 265 (64%) | 230 (71%) | 140 (63%) | 0.01 | |
| G | 443 (35%) | 112 (41%) | 147 (36%) | 92 (29%) | 84 (37%) | ||
| CC | 344 (56%) | 62 (46%) | 118 (57%) | 105 (65%) | 59 (53%) | 0.02 | 1c |
| CG | 105 (17%) | 34 (25%) | 29 (14%) | 20 (12%) | 22 (20%) | ||
| GG | 169 (27%) | 39 (29%) | 61 (29%) | 37 (22%) | 32 (28%) | ||
| rs2302267 | |||||||
| T | 1085 (88%) | 241 (89%) | 364 (87%) | 281 (87%) | 199 (88%) | 0.87 | |
| G | 151 (12%) | 29 (11%) | 52 (13%) | 43 (13%) | 27 (12%) | ||
| TT | 521 (84%) | 115 (85%) | 174 (84%) | 136 (85%) | 96 (85%) | 0.89 |
0.17c |
| TG | 43 (7%) | 11 (8%) | 16 (8%) | 9 (6%) | 7 (6%) | ||
| GG |
54 (9%) |
9 (7%) |
18 (9%) |
17 (10%) |
10 (9%) |
||
|
MyD88 | |||||||
| rs7744 | |||||||
| A | 954 (77%) | 224 (83%) | 315 (76%) | 245 (76%) | 170 (75%) | 0.08 | |
| G | 282 (23%) | 46 (17%) | 101 (24%) | 79 (24%) | 56 (25%) | ||
| A/A | 370 (60%) | 92 (68%) | 120 (58%) | 93 (57%) | 65 (57%) | 0.64 | |
| A/G | 214 (35%) | 40 (30%) | 75 (36%) | 59 (36%) | 40 (35%) | 0.34 | |
| G/G | 34 (5%) | 3 (2%) | 13 (6%) | 10 (6%) | 8 (7%) | ||
a
Chi square test.
b
HWE (Hardy Weinberg Equilibrium).
c
HWE in women. Text in bold denotes statistical significance.