Table 3.
Genotypes of TLR7 and MyD88 variant genes with clinical characteristics.
| TLR7 | ||||
|---|---|---|---|---|
| rs3853839 | CC | CG | GG | Pa |
| Oxygen saturation % | 88 (80–93) | 89 (82–95) | 86.5 (78–93) | 0.09 |
| Platelets ×109/L | 230 (167–295) | 260 (204–321) | 240 (186–308) | 0.18 |
| Ferritin (ng/mL) | 493.7(259.8–904.3) | 230.6(96.6–489.3) | 511.5(257–987.9) | <0.001 |
| D Dimer (ng/mL) | 278.5 (61.4–690) | 348.5 (120–677) | 319 (90.3–754) | 0.76 |
| C-Reactive Protein (mg/L) | 20.05(6.8–90) | 13.03(3.1–31.73) | 19.67(6.11–61.73) | 0.04 |
| DHL (U/L) | 279.5(202–436.5) | 251.9(159.2–354) | 327.1(228–453) | <0.001 |
| IFNα (pg/mL) | 17.9 (9.7–34.3) | 15.5 (9.6–23.6) | 18.2 (11.4–40.9) | 0.21 |
| rs179008 | AA | AG | GG | |
| Oxygen saturation % | 87 (78–93) | 90 (83–94) | 89 (80–94) | 0.15 |
| Platelets ×109/L | 238.5 (185–310) | 250 (193–289) | 231 (164–300) | 0.41 |
| Ferritin (ng/mL) | 463(219–888.3) | 159.9(42.1–503.2) | 529.1(259.8–1000) | <0.001 |
| D Dimer (ng/mL) | 313 (74.7–672.4) | 263 (77–616) | 294.35 (84–828) | 0.62 |
| C-Reactive Protein (mg/L) | 18.98(5.30–66.96) | 10.2(3.53–24.81) | 20.83(5.5–123.49) | 0.01 |
| DHL (U/L) | 309.5(214–448) | 233.95(147–323) | 313.9(221.5–442) | 0.001 |
| IFNα (pg/mL) | 18.12 (10.8–34.7) | 19.8 (9.8–31.8) | 16.05 (9.8–26.1) | 0.66 |
| rs179009 | AA | AG | GG | |
| Oxygen saturation % | 87 (77–92) | 90 (82–94) | 88 (79–93) | 0.09 |
| Platelets ×109/L | 237 (184–305) | 252 (198–320) | 226 (174–300) | 0.13 |
| Ferritin (ng/mL) | 486.5(237–894.1) | 170.35(46–433.9) | 580.3(259.8–1021.6) | <0.001 |
| D Dimer (ng/mL) | 297 (73–627) | 286 (77–666) | 322.7 (87–793.43) | 0.46 |
| C-Reactive Protein (mg/L) | 18.03(5.39–62.32) | 11.05(2.6–28.42) | 22.35(7.1–90) | 0.006 |
| DHL (U/L) | 308(217–443.7) | 219.5(154–323) | 334.2(238–456.5) | <0.001 |
| IFNα (pg/mL) | 17.6 (10.8–34.3) | 20.4 (12.3–31.8) | 17.6 (10.4–33.8) | 0.6 |
| rs2302267 | TT | TG | GG | |
| Oxygen saturation % | 87 (79–93) | 90.5 (83–95) | 85 (71–93) | 0.05 |
| Platelets ×109/L | 235 (180–307) | 250 (204–336) | 230 (185–295) | 0.30 |
| Ferritin (ng/mL) | 457.3(205.1–885.9) | 212.25(61–390.6) | 584.4(387.7–1042.1) | <0.001 |
| D Dimer (ng/mL) | 325.5 (83.15–751) | 260 (77–564) | 162.05 (44.1–465) | 0.07 |
| C-Reactive Protein (mg/L) | 18.34 (5.3–62.9) | 9.7 (5–71.55) | 20.24 (5.72–163.72) | 0.32 |
| DHL (U/L) | 306.30(211–438) | 209.15(158.5–269.7) | 360.75(250–480) | <0.001 |
| IFNα (pg/mL) | 18.2 (10.7–33.8) | 14.3 (9.9–19.7) | 17.6 (11.9–50.4) | 0.31 |
| MyD88 | ||||
| rs7744 | AA | AG | GG | |
| Oxygen saturation % | 88 (80–93) | 87 (77–93) | 83 (71–92) | 0.09 |
| Platelets ×109/L | 237 (178–303) | 233 (184–304.5) | 271 (204–331) | 0.39 |
| Ferritin (ng/mL) | 487 (184.6–888.3) | 438.3 (225–865.4) | 359.3 (208.4–558.9) | 0.81 |
| D Dimer (ng/mL) | 281.3(74.5–665.5) | 291(69.5–683.5) | 547.75(260–845) | 0.03 |
| C-Reactive Protein (mg/L) | 17.12 (4.65–82.9) | 17.65 (5.42–51.74) | 24.5 (18.31–38.51) | 0.30 |
| DHL (U/L) | 304 (202–438.5) | 293.6 (212.1–436.5) | 324 (276–389) | 0.62 |
| IFNα (pg/mL) | 18.16 (11.8–37.2) | 17.6 (9.7–27.4) | 17.02 (6.14–22.6) | 0.16 |
IQR = Interquartile Range.
a
Kruskal–Wallis test. Chi square test.