Table 4.

Association of TLR7 and MyD88 polymorphisms with COVID-19 outcomes.

Polymorphisms	Severe			Critical			Deceased
	ORa	95% CI	P	ORa	95% CI	P	ORa	95% CI	P
TLR7
rs179008
A	Reference			Reference			Reference
T	0.86	0.56–1.30	0.48	0.94	0.60–1.47	0.79	0.67	0.37–1.19	0.17
AA	Reference			Reference			Reference
AT	0.54	0.21–1.37	0.19	1.40	0.54–3.61	0.48	0.91	0.25–3.24	0.89
TTc	0.93	0.48–1.81	0.84	0.85	0.41–1.77	0.67	0.61	0.24–1.52	0.28
AT + TTd	0.74	0.42–1.32	0.32	1.26	0.66–2.40	0.47	0.75	0.32–1.78	0.52
TTr	0.94	0.47–1.87	0.87	0.97	0.45–2.11	0.95	0.66	0.22–1.17	0.45
Log additive	0.89	0.64–1.24	0.51	0.85	0.54–1.34	0.50	0.82	0.49–1.37	0.46
rs179009
A	Reference			Reference			Reference
G	0.74	0.52–1.06	0.10	0.79	0.54–1.17	0.25	0.86	0.53–1.38	0.54
AA	Reference			Reference			Reference
AG	0.65	0.29–1.46	0.30	0.38	0.15–0.99	0.05	0.35	0.11–1.14	0.08
GGc	0.70	0.39–1.26	0.24	0.81	0.44–1.4	0.50	0.91	0.43–1.93	0.82
AG + GGd	0.69	0.41–1.14	0.15	0.67	0.38–1.17	0.16	0.71	0.36–1.41	0.33
GGr	1.08	0.64–1.82	0.75	1.19	0.67–2.09	0.54	1.42	0.71–2.83	0.31
Log additive	0.82	0.62–1.09	0.19	0.87	0.64–1.17	0.37	0.91	0.63–1.32	0.63
rs3853839
C	Reference			Reference			Reference
G	1.09	0.75–1.56	0.64	1.83	1.21–2.75	0.004	1.36	0.83–2.23	0.21
CC	Reference			Reference			Reference
CG	0.83	0.34–1.99	0.68	1.16	0.41–3.25	0.78	2.02	0.56–7.20	0.27
GGc	1.09	0.61–1.95	0.75	1.98	1.04–3.77	0.03	1.57	0.70–3.52	0.26
CG + GGd	0.86	0.50–1.48	0.59	1.85	0.98–3.49	0.05	1.17	0.56–2.43	0.67
GGr	1.49	0.91–2.44	0.10	1.91	1.08–3.39	0.03	1.28	0.63–2.58	0.49
Log additive	1.09	0.82–1.45	0.51	1.42	1.03–1.96	0.03	1.22	0.83–1.81	0.30
rs2302267
T	Reference			Reference			Reference
G	0.72	0.40–1.28	0.26	1.10	0.61–1.99	0.73	0.64	0.29–1.40	0.26
TT	Reference			Reference			Reference
TG	1.34	0.48–3.72	0.56	1.24	0.38–4.02	0.72	1.23	0.42–3.55	0.70
GGc	0.52	0.19–1.41	0.20	1.14	0.43–2.98	0.88	1.01	0.40–2.51	0.98
TG + GGd	0.71	0.35–1.44	0.34	1.03	0.49–2.16	0.93	0.71	0.25–1.97	0.51
GGr	0.76	0.29–2.00	0.58	1.53	0.58–4.02	0.38	0.53	0.15–1.85	0.32
Log additive	0.82	0.53–1.28	0.40	1.11	0.70–1.74	0.64	0.77	0.42–1.40	0.39
MyD88
Rs7744
A	Reference			Reference			Reference
G	1.58	1.01–2.45	0.04	1.76	1.10–2.82	0.02	2.45	1.38–4.34	0.002
A/A	Reference			Reference			Reference
A/G	1.66	0.96–2.84	0.06	1.69	0.94–3.05	0.08	2.03	0.97–4.25	0.06
G/Gc	2.34	0.58–9.40	0.23	3.51	0.86–14.24	0.07	8.83	1.82–42.23	0.007
A/G + G/Gd	1.70	1.02–2.86	0.04	1.82	1.04–3.21	0.03	2.44	1.21–4.9	0.01
G/Gr	1.96	0.49–7.77	0.33	2.91	0.73–11.64	0.13	6.75	1.45–31.33	0.01
Log additive	1.61	1.02–2.54	0.04	1.75	1.09–2.84	0.02	2.41	1.35–4.32	0.003

^aAdjusted for age, sex, hypertension, type 2 diabetes, and obesity. d: dominant inheritance model, the reference group is formed by the major allele homozygote genotype; r: recessive inheritance model, the reference group is formed by the major allele homozygote and heterozygote genotypes. The text in bold denotes statistical significant.