Table 1.
Baseline Characteristics of all patients included
| Andexxa N=28 |
4F-PCC N=16 |
p | |
|---|---|---|---|
| Age (years) | 78 [70 – 87] | 80 [74 – 84] | 0.88 |
| Gender, female | 11 (39) | 5 (31) | 0.84 |
| Race | |||
| African American | 2 (7) | 1 (6) | 0.84 |
| White or Caucasian | 24 (86) | 13 (81) | |
| Patient Refused/Unknown | 2 (7) | 2 (13) | |
| BMI (kg/m2) | 28 [22 – 44] | 28 [26 – 33] | 0.94 |
| Baseline SrCr (mg/dL) | 1.1 [0.8 – 1.3] | 0.91 [0.6 – 1.1] | 0.17 |
| GCS on admission | 14 [11 – 15] | 14 [7 – 15] | 0.65 |
| Past Medical History | |||
| Atrial Fibrillation | 20 (71) | 10 (62) | 0.74 |
| Myocardial Infarction | 8 (29) | 1 (6) | 0.12 |
| Stroke | 8 (29) | 1 (6) | 0.12 |
| Deep Venous Thrombosis | 4 (14) | 2 (12) | 1.00 |
| Pulmonary Embolism | 5 (18) | 2 (12) | 1.00 |
| Heart Failure | 7 (25) | 2 (12) | 0.45 |
| Diabetes Mellitus | 9 (32) | 2 (12) | 0.28 |
| Coronary Artery Disease | 5 (18) | 1 (6) | 0.40 |
| Concomitant medication | |||
| Aspirin | 11 (39) | 1 (6) | 0.03 |
| Clopidogrel | 2 (7) | 0 (0) | 0.53 |
| Anticoagulation Indication | |||
| Atrial Fibrillation/flutter | 21 (75) | 13 (81) | 1.00 |
| Deep Venous Thrombosis | 6 (21) | 3 (19) | |
| Other | 1 (4) | 0 (0) | |
| Apixaban | 19 (68) | 12 (75) | 0.74 |
| 5 mg twice daily | 14 | 11 | 0.36 |
| 2.5 mg twice daily | 5 | 1 | |
| Rivaroxaban | 9 (32) | 4 (25) | 0.74 |
| 20 mg daily | 4 | 4 | 0.30 |
| 15 mg daily | 4 | 0 | |
| Dose unknown | 1 | 0 | |
| Hemorrhage Type | |||
| Spontaneous ICH | 20 (71) | 8 (50) | 0.20 |
| IPH with or without IVH | 13 (46) | 6 (38) | |
| IVH without IPH | 2 (7) | 0 | |
| SAH | 2 (7) | 0 | |
| Hemorrhagic conversion of ischemic stroke | 1 (3.6) | 1 (6) | |
| SDH | 1 (3.6) | 0 | |
| Hemorrhagic Tumor | 1 (3.6) | 1 (6) | |
| Traumatic ICH | 8 (29) | 8 (50) | |
| Multicompartmental hemorrhage | 7 (25) | 5 (31) | |
| SDH | 0 | 3 (19) | |
| Contusions | 1 (4) | 0 | |
| IPH Hematoma Volume (mL) | |||
| Hematoma volume Baseline | 8.5 [5.8 – 23] | 11 [8.3 – 46.6] | 0.22 |
Nominal data presented as n (%) and continuous data as median [IQR]
BMI, body mass index; GCS, Glasgow coma scale; IPH, intraparenchymal hemorrhage; IVH, intraventricular hemorrhage; SAH, subarachnoid hemorrhage; SDH, subdural hematoma; SrCr, serum creatinine