Table 2.
Outcomes for all patients included
| Andexxa N=28 |
4F-PCC N=16 |
p | P adjusted | |
|---|---|---|---|---|
| CT Scan Stability | ||||
| All Included Patients | ||||
| Stable CT scan at 6 hr* | 21 (78) | 10 (71) | 0.71 | 0.62 |
| Stable CT scan at 24 hr± | 15 (88) | 6 (60) | 0.15 | 0.10 |
| Spontaneous IPH only | ||||
| Stable CT scan at 6 hr¶ | 13 (87) | 4 (100) | 1.00 | 0.91 |
| Stable CT scan at 24 hrǁ | 7 (87) | 4 (100) | 1.00 | 0.74 |
| Spontaneous IPH Hematoma volume (mL) | ||||
| Hematoma Volume at 6 h post reversal¶ | 9.3 [6.9 – 26.4] | 10 [9.4 – 22.1] | 0.67 | 0.997 |
| Hematoma volume at 24 hours post reversalǁ | 9.2 [6.1 – 18.8] | 9.9 [9.4 – 21.1] | 0.57 | 1 |
| Unstable CT scan at 24 hr± | ||||
| Non-traumatic ICH | ||||
| IVH without IPH | 1 | 0 | 1 | |
| Traumatic ICH | ||||
| SDH | 0 | 1 | 0.242 | |
| Multicompartment bleed | 1 | 3 | ||
| Good Outcome (mRS <=3) on discharge | 10 (36) | 6 (38) | 1 | 0.81 |
| Mortality | ||||
| Death/Hospice on discharge | 11 (39) | 6 (38) | 1 | 0.86 |
| Length of Stay | ||||
| Hospital LOS | 7 [4 – 15] | 6 [2 – 11] | 0.20 | |
| ICU LOS | 2 [1 – 4] | 4 [1 – 8] | 0.38 | |
| VTE Events | ||||
| Deep Venous Thrombosis on discharge | 2 (7) | 0 (0.0) | 0.53 | |
| Disposition | ||||
| ARF | 5 (18) | 1 (6) | 0.71 | |
| Dead/Hospice | 11 (39) | 6 (38) | ||
| Home | 6 (21) | 4 (25) | ||
| SNF | 6 (21) | 5 (31) |
Nominal data presented as n (%) and continuous data as median [IQR]
ARF, acute rehab facility; CT, computed tomography; ICU, intensive care unit; IPH, intraparenchymal hemorrhage; LOS, length of stay; mRS, Modified Rankin Score; SNF, skilled nurse facility; VTE, venous thromboembolic.
*
Evaluable CT-scans AA=27, 4F-PCC=14;
±
Evaluable CT-scans AA=17, 4F-PCC=10;
¶
Evaluable CT-scans AA=15, 4F-PCC=4;
ǁ
Evaluable CT-scans AA=8, 4F-PCC=4