Table 1:

Known and predicted impacts of helminth infection on the production of microbial-derived metabolites.

Helminth	Host	Bacterial metabolite or metabolic pathway	Consequence for the host	Reference
Ascaris lumbricoides, Necator americanus, Trichuris trichiura	Homo sapiens	↑Arachidonic acid metabolism	Predicted to alter host resistance to intestinal helminths	23
T. muris	Mus musculus	↑Ethanolamine utilization	↑ T. muris egg hatching	5
H. polygyrus	Mus musculus	↑SCFA	↓Allergic airway inflammation	29
H. diminuta	Mus musculus	↑SCFA	↓Chemical-induced colitis	30
ES-62 secreted by A. vitea	Mus musculus	↑SCFA	↓Collagen-induced arthritis	32
H. polygyrus	Mus musculus	↑SCFA	↓HFD-induced weight gain and glucose intolerance	33
H. polygyrus	Mus musculus	↑NE	↑Adipose tissue beiging and ↓weight gain with HFD	34
H. polygyrus	Mus musculus	↓Undefined protective metabolites	↑Invasion of intestinal epithelial cells by Salmonella Typhimurium	36