Table 3.

National and international guidelines used by experts as reference for the management of HDMTX-induced toxicity.

Guide	Source	Percentage of experts (n = 10)
SEHOP-PETHEMA Protocol for the treatment of new diagnostic acute lymphoblastic leukaemia	SEHOP-PETHEMA 29	40%
GEL-TAMO Guide for the diagnostic, prevention and management of patients with diffuse large b-cell lymphoma	GEL-TAMO 30	30%
SEHOP-PETHEMA Protocol for the treatment of high-risk Acute Lymphoblastic Leukaemia BCR/ABL negative in adults	SEHOP-PETHEMA 31	20%
Consensus guidelines for the use of glucarpidase	Ramsey et al. 2018 7	10%

GEL-TAMO = Spanish Group of Lymphoma and Bone marrow transplant; SEHOP-PETHEMA = Spanish Program of Haematologic Treatments and Spanish Society of Haematology and Paediatric Oncology.