Table 5.

Incidence of grade 3 non-renal systemic toxicities in patients with HDMTX-induced AKI.

Type of toxicity	Percentage of patients presenting grade 3 toxicity
	Experts reporting the toxicity (n)	≤ 20%	21–40%	41–60%	61–80%	>80%	Median class
Haematologic	10	4	4	-	1	1	21–40%
Mucositis	10	4	4	1	-	1	21–40%
Hepatic	10	7	-	3	-	-	≤20%
Myelotoxicity	10	6	1	1	-	2	≤20%
Gastrointestinal	9	5	4	-	-	-	≤20%
Infections	8	5	1	2	-	-	≤20%
Neurologic	7	5	1	1	-	-	≤20%
Pulmonary	5	5	-	-	-	-	≤20%