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[Preprint]. 2023 Jun 5:2023.06.02.543504. [Version 1] doi: 10.1101/2023.06.02.543504

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Figure 1: — a) anatomical representation of the perivascular space (PVS) in the brain vasculature. PVS surrounds the blood vessel lumen. It is involved in the fluid exchange between blood vessels and brain parenchyma through the aquaporin 4 channels, located on the astrocyte endfeet. b) during neuroinflammation, lymphocytes cross the endothelial cell layer as a result of blood brain barrier leakage Perivascular macrophages (PVMs) then form, leading to PVS enlargements. As a result, there is a higher accumulation of neurotoxins such as amyloid beta, leading to neural death.