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[Preprint]. 2023 Jun 7:2023.06.05.543735. [Version 1] doi: 10.1101/2023.06.05.543735

Figure 6.

Figure 6.

Pan Eph receptor inhibitors demonstrates neuroprotective properties, preserving retinal ganglion cell dendritic arborization as observed by confocal microscopy following ONC injury. (A) Quantification of retinal ganglion cell dendritic arborization by sholl analysis 6 days after ONC injury. Animals treated with 50 μM of UniPR129 (pan Eph receptor A inhibitor), (N = 3 biological replicates). (B) Quantification of retinal ganglion cell dendritic arborization by sholl analysis 6 days after ONC injury. Animals treated with 2 μM of NVP-BHG712 (pan Eph receptor B inhibitor), (N = 3 biological replicates). (C) Quantification of retinal ganglion cell dendritic arborization by sholl analysis 6 days after ONC injury. Animals treated with a combination of both UniPR129 (50 mM) and NVP-BHG712 (2 mM) pan Eph receptor A&B inhibitors), (N = 3 biological replicates). Mann-Whitney U tests and a p value of p ≤ 0.05 is considered statistically significant. Scale bar at 50 μm.