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[Preprint]. 2023 Jun 5:2023.06.02.543481. [Version 1] doi: 10.1101/2023.06.02.543481

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Figure 3. — α-synuclein interacts directly with β-spectrin but not α-spectrin. A, Human α-synuclein and Drosophila β-spectrin interact in Ni-NTA and glutathione-S-transferase (GST) pull-down assays as monitored by immunoblotting for β-spectrin (His) or α-synuclein. B, No interaction of human α-synuclein and Drosophila α-spectrin in Ni-NTA or GST pull-down assays as monitored by immunoblotting for β-spectrin (His) or α-synuclein. C, Human α-synuclein and human βII-spectrin interact in Ni-NTA and GST pull-down assays as monitored by immunoblotting for βII-spectrin (His) or α-synuclein. D, No interaction of human α-synuclein and human αII-spectrin in Ni-NTA or GST pull-down assays as monitored by immunoblotting for αII-spectrin (His) or α-synuclein. E, Immunoprecipitation of α-synuclein in control and α-synuclein transgenic flies shows an association between α-synuclein and β-spectrin. Flies are 10 days old.