Table 1:
Summary of temperature responsive SMYD5-regulated genes.
| SMYD5-repressed genes ↑ at 32°C (SMYD5 represses at 37°C) | ||
|---|---|---|
| Gene | Function | Role |
|
| ||
| Mybl2 | Transcription factor | Cell-cycle control |
| Klf15 | Transcription factor | Brown-tissue metabolism |
| Thrap3 | Transcriptional co-activator | Thyroid hormone receptor binding |
| Tex15 | DNA repair protein | Role in testicular meiosis |
| Ewsr1 | RNA binding | Role in Ewing sarcoma |
| Tfcp2l1 | Transcription factor | Pluripotency in stem cells |
| Amotl2 | Angiostatin binding factor | Role in angiogenesis |
| Phf20 | Methyl-lysine-binding protein | Histone modification |
| Cd24a | Sialoglycoprotein | Cell differentiation |
| Nt5e | Nucleotidase | Nucleotides metabolism |
| Neo1 | Cell surface receptor | Immunoglobulin superfamily |
| Gabbr1 | GABA receptor | Inhibitory neurotransmitter |
| Asxl1 | Chromatin binding protein | Polycomb family member |
| Tulp4 | Tubby Superfamily Protein | Ubiquitination function |
| Pkn1 | Serine/threonine-protein kinase | Protein kinase C superfamily |
| Hnrnpul1 | RNA-binding protein | hnRNP family |
| Mier1 | Transcriptional regulator | Mesoderm induction early response |
| Fam21 | WASH complex member | Endosomal protein sorting |
| Trip12 | E3 ubiquitin-protein ligase | Ubiquitin regulation and DNA repair |
| Lamc1 | Extracellular matrix glycoprotein | A laminin |
| Rell1 | RELT-like protein | Regulates the p38MAPK cascade |
| Xrn2 | 5'-3' exonuclease | Promotes transcription termination |
| Hspg2 | Multidomain proteoglycan | Encodes Perlecan protein |
| Ctc1 | Telomere maintenance protein | Limits telomere degradation |
| Stag1 | Component of cohesin complex | Role in cohesion of sister chromatids |
| Ass1 | Enzyme | Role in urea cycle |
| SMYD5-upregulated genes ↓ at 32°C (SMYD5 activates at 37°C) | ||
| Gene | Function | Role |
|
| ||
| Usp28 | Ubiquitin Thioesterase | DNA damage checkpoint |
| Ccnd1 | Cyclin D | Cell cycle regulation |
| Dzip3 | Ubiquitin-protein transferase | Spermatogenesis |
| Rad50 | DNA double-strand break repair | Cell cycle regulation |
| Arglu1 | Enables cadherin binding | Mediator complex |
| Sltm | RNA binding activity | Regulation of transcription |
| Slc16a3 | Solute transporter | Lactic acid and pyruvate transport |
| Ier5l | Unknown function | Parolog of IER5 |
| Acly | Enzyme | Synthesis of cytosolic acetyl-CoA |
| Agps | Enzyme | Lipid biosynthesis |
| Apobec3 | Cytidine deaminase | RNA editing |
| Ivns1abp | Viral binding protein | Response to viral infection |
| Dus3l | Synthesis of dihydrouridine | RNA editing |
| Upp1 | Uridine phosphorylase | Ribonucleosides dynamics |
| Ldha | Enzyme | Lactate to Pyruvate conversion |
| Scd2 | Enzyme | Fatty acid biosynthesis |
| Smarcad1 | Chromatin remodeler | Role in heterochromatin formation |
| Bnip3l | Pro-apoptotic protein | Induces apoptosis |
| Esrra | Nuclear receptor | Mitochondrial biogenesis regulator |