Table 1. Mean ± S.D of all the measured parameters in brain homogenate of PPA treated male and female mice groups compared to control group. Only P values ≤0.05 were considered significant.

Parameters	Groups	N	Min.	Max.	Mean ± S.D.	P value a	P value b
IL- 6 (pg/ml)	Control Male	10	34.25	45.13	38.90 ± 3.41	0.786	0.688
	PPA Treated Male	6	21.27	86.11	42.99 ± 22.36
	Control Female	9	20.21	43.03	34.50 ± 6.98	0.084
	PPA Treated Female	6	30.49	48.76	41.29 ± 6.74
IL-10 (pg/ml)	Control Male	10	2121.20	2712.10	2395.60 ± 140.33	0.017	0.593
	PPA Treated Male	6	2318.20	3444.40	2939.40 ± 361.78
	Control Female	9	2186.90	2409.10	2287.90 ± 56.23	0.001
	PPA Treated Female	6	2399.00	3368.80	2831.70 ± 311.96
Glu (nmol/ml)	Control Male	10	17.68	22.00	20.09 ± 1.33	0.046	0.001
	PPA Treated Male	6	11.24	19.81	16.70 ± 3.15
	Control Female	9	13.14	18.88	16.30 ± 1.93	0.001
	PPA Treated Female	6	22.37	26.13	23.87 ± 1.71
GABA (pg/ml)	Control Male	10	33.43	48.78	42.59 ± 4.30	0.026	0.123
	PPA Treated Male	6	43.63	52.77	47.62 ± 3.11
	Control Female	9	45.34	48.50	46.95 ± 0.82	0.001
	PPA Treated Female	6	48.62	51.41	49.84 ± 0.90
LDH (U/ml)	Control Male	10	720.73	1182.17	1020.42 ± 126.37	0.021	0.094
	PPA Treated Male	6	522.97	1010.77	751.12 ± 204.27
	Control Female	9	637.23	1164.59	852.58 ± 136.27	0.246
	PPA Treated Female	6	652.61	1241.49	987.34 ± 236.88
CK (IU/ml)	Control Male	10	582.29	1357.95	968.29 ± 261.51	0.660	0.337
	PPA Treated Male	6	430.68	2190.74	1063.88 ± 593.49
	Control Female	9	465.83	1786.43	1027.49 ± 453.95	0.321
	PPA Treated Female	6	509.78	1292.03	811.55 ± 283.89
GSH (µg/ml)	Control Male	10	9.49	12.34	11.19 ± 0.88	0.307	0.873
	PPA Treated Male	6	6.01	14.24	9.81 ± 2.93
	Control Female	9	7.91	14.24	10.64 ± 1.92	0.954
	PPA Treated Female	6	6.96	17.72	10.55 ± 4.11
GST (U/ml)	Control Male	10	0.23	0.37	0.31 ± 0.04	0.060	0.234
	PPA Treated Male	6	0.21	0.33	0.26 ± 0.04
	Control Female	9	0.21	0.37	0.28 ± 0.06	0.545
	PPA Treated Female	6	0.23	0.39	0.30 ± 0.05
Catalase (U/ml)	Control Male	10	0.00	0.01	0.007 ± 0.002	0.012	0.225
	PPA Treated Male	6	0.01	0.02	0.012 ± 0.005
	Control Female	9	0.00	0.01	0.008 ± 0.003	0.205
	PPA Treated Female	6	0.01	0.01	0.010 ± 0.001

Notes.

^aP value between control and corresponding PPA traded group.

^bP value between PPA treated groups.