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. 2023 Jun 13;11:e15488. doi: 10.7717/peerj.15488

Table 3. Alterations in repetitive behavior, cognitive ability, and physical-neural coordination capability in PPA treated male and female mice groups compared to control (N = 6).

Indicators Parameters Groups Mean ± S.D. Significancy
A. Indicators of repetitive behavior and anxiety Number of Squares crossed Control Male 207.47 ± 37.09
Control Female 167.17 ± 47.06
PPA Treated Male 265.67 ± 72.50 **
PPA Treated Female 262.33 ± 65.23 *
Wall rear Control Male 19.17 ± 3.69
Control Female 17.00 ± 5.29
PPA Treated Male 27.00 ± 5.29 **
PPA Treated Female 27.67 ± 7.64 *
Rear Control Male 6.67 ± 7.02
Control Female 6.00 ± 5.57
PPA Treated Male 8.00 ± 5.00 *
PPA Treated Female 8.00 ± 6.56 *
Locomotion Duration (sec) Control Male 214.33 ± 48.69
Control Female 193.33 ± 13.43
PPA Treated Male 282.00 ± 19.08 **
PPA Treated Female 266.33 ± 14.29 *
Immobility Duration (sec) Control Male 88.67 ± 43.75
Control Female 70.67 ± 13.65
PPA Treated Male 24.67 ± 15.04 *
PPA Treated Female 29.33 ± 16.80 *
B. Indicators of cognitive ability Total latency time (La) Control Male 110.17 ± 9.56
Control Female 98.67 ± 5.57
PPA Treated Male 135.67 ± 5.09 **
PPA Treated Female 122.50 ± 5.58 **
Number of crossings during light and sound stimulus (St) Control Male 2.17 ± 0.75
Control Female 1.83 ± 0.75
PPA Treated Male 0.50 ± 0.55 **
PPA Treated Female 1.33 ± 0.52
Number of reinforced crossings during the shock (Re) Control Male 22.00 ± 1.90
Control Female 12.17 ± 1.94
PPA Treated Male 21.50 ± 5.58
PPA Treated Female 18.67 ± 2.88 **
Number of no crossing during the shock (Tr) Control Male 2.33 ± 0.52
Control Female 2.83 ± 0.75
PPA Treated Male 3.17 ± 0.75 *
PPA Treated Female 3.67 ± 1.03
C. Indicator of physical and coordination capability Motor voltage measurement by wheels Control Male 3.67 ± 1.03
Control Female 3.17 ± 0.75
PPA Treated Male 2.83 ± 0.75
PPA Treated Female 2.33 ± 0.52 *