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[Preprint]. 2023 Jun 5:2023.06.02.543478. [Version 1] doi: 10.1101/2023.06.02.543478

Figure 2. RTT mutations differentially perturb MeCP2 behavior on DNA.

Figure 2.

a, Domain structure of MeCP2 and the corresponding PONDR disorder score. Three RTT mutants (T158M, P225R, and R270X) are shown below the WT protein. b, Apparent on rate for WT, T158M, P225R, or R270X MeCP2 binding to unmethylated or methylated DNA. Error bars represent SD. c, Average MSD plot for WT (n = 78), T158M (n = 20), P225R (n = 40), or R270X (n = 44) Cy3-MeCP2 trajectories on unmethylated DNA. Error bars represent SD. d, Estimated number of monomers per trajectory for WT, T158M, P225R, or R270X MeCP2 on unmethylated DNA. Bars represent mean and SD.