Table 1.
Demographics and Clinical information of Control and Cases with NEC/SIP
| N | N = 163 | Control N = 54 | Surgical NEC/SIP = 109 | p | |
|---|---|---|---|---|---|
| Gestational Age (weeks, median, IQR) | 163 | 26.4 [24.3;28.4] | 27.4 [26.0;30.3] | 25.4 [24.0;27.3] | <0.001 |
| Birth Weight (g, median, IQR) | 163 | 820 [655;1025] | 990 [780;1303] | 730 [620;940] | <0.001 |
| Small for gestation, n (%) | 163 | 10 (18.5%) | 37 (34.9%) | 47 (29.4%) | 0.049 |
| Male, n (%) | 163 | 94 (57.7%) | 27 (50.0%) | 67 (61.5%) | 0.22 |
| Ethnicity, n (%) | 160 | 0.017 | |||
| African American | 127 (79.4%) | 43 (81.1%) | 84 (78.5%) | ||
| Caucasian | 25 (15.6%) | 5 (9.43%) | 20 (18.7%) | ||
| Hispanic | 4 (2.50%) | 4 (7.55%) | 0 (0.00%) | ||
| Other | 4 (2.50%) | 1 (1.89%) | 3 (2.80%) | ||
| Cesarean-section, n (%) | 162 | 110 (67.9%) | 35 (66.0%) | 75 (68.8%) | 0.861 |
| Antenatal Steroid Use, n (%) | 149 | 116 (77.9%) | 45 (91.8%) | 71 (71.0%) | 0.008 |
| Apgar score < 6 at 5 min, n (%) | 160 | 38 (23.8%) | 8 (15.1%) | 30 (28.0%) | 0.107 |
| Day of life of severe ROP diagnosis (days), median (IQR) | 162 | 49.0 [42.0;68.8] | 45.0 [35.0;48.0] | 60.0 [44.0;75.0] | <0.001 |
| Corrected gestational age of severe ROP diagnosis (days), median (IQR) | 163 | 34.3 [33.0;36.0] | 34.0 [32.9;35.1] | 34.4 [33.1;36.1] | 0.064 |
| Type 1 ROP n (%) | 163 | 25 (15.3%) | 1 (1.85%) | 24 (22.0%) | 0.002 |
| Type 2 ROP n (%) | 163 | 9 (5.52%) | 1 (1.85%) | 8 (7.34%) | 0.274 |
| No ROP n (%) | 163 | 94 (57.7%) | 45 (83.3%) | 49 (45.0%) | <0.001 |
| Laser, n (%) | 163 | 20 (12.3%) | 1 (1.85%) | 19 (17.4%) | 0.009 |
| Avastin, n (%) | 163 | 12 (7.36%) | 0 (0.00%) | 12 (11.0%) | 0.009 |
| Both, n (%) | 163 | 6 (3.68%) | 0 (0.00%) | 6 (5.50%) | 0.179 |
| Length of Stay (days, median ± SD) | 162 | 97.0 [65.5;165] | 77.0 [63.0;99.0] | 117 [72.0;171] | 0.001 |
| Death, n (%) | 163 | 39 (23.9%) | 2 (3.70%) | 37 (33.9%) | <0.001 |