Table 2.
Demographic and clinical information in infants with any ROP and no ROP in NEC/SIP cohort
| N = 109 | No ROP, N = 49 | ROP, N = 60 | p | ||
|---|---|---|---|---|---|
| Day of life at no ROP (days), median (IQR) | 47.0 [42.0;57.0] | 44.0 [40.0;56.0] | 52.0 [43.0;57.2] | 0.017 | |
| Day of life of severe ROP diagnosis (days), median (IQR) | 60.0 [44.0;75.0] | 44.0 [40.0;56.0] | 70.5 [60.8;87.0] | <0.001 | |
| Corrected gestational age of severe ROP diagnosis (days), median (IQR) | 34.4 [33.1;36.1] | 33.7 [32.6;35.2] | 34.8 [33.7;37.0] | 0.015 | |
| Type 1 ROP n (%) | 24 (22.0) | 0 (0.00) | 24 (40.0) | <0.001 | |
| Type 2 ROP n (%) | 8 (7.34) | 0 (0.00) | 8 (13.3) | 0.008 | |
| No ROP n (%) | 49 (45.0) | 49 (100) | 0 (0.00) | <0.001 | |
| Laser, n (%) | 19 (17.4) | 0 (0.00) | 19 (31.7) | <0.001 | |
| Avastin, n (%) | 12 (11.0) | 0 (0.00) | 12 (20.0) | 0.003 | |
| Both, n (%) | 6 (5.50) | 0 (0.00) | 6 (10.0) | 0.032 | |
| Prenatal information | |||||
| Pregnancy-induced hypertension, n (%) | 31 (29.2) | 20 (41.7) | 11 (19.0) | 0.019 | |
| Chronic hypertension, n (%) | 15 (15.8) | 7 (15.9) | 8 (15.7) | 0.99 | |
| Chorioamnionitis, n (%) | 12 (11.4) | 1 (2.13) | 11 (19.0) | 0.017 | |
| Antenatal steroids, n (%) | 71 (71.0) | 30 (66.7) | 41 (74.5) | 0.521 | |
| Infant demographics | |||||
| Gestational age (weeks) (median [IQR]) | 25.4 [24.0;27.3] | 27.3 [26.3;29.3] | 24.4 [23.5;25.4] | <0.001 | |
| Birth weight (g) (median [IQR]) | 730 [620;940] | 935 [700;1180] | 665 [556;776] | <0.001 | |
| Small for gestational age, n (%) | |||||
| Male, n (%) | 67 (61.5) | 34 (69.4) | 33 (55.0) | 0.181 | |
| Race, n (%) | 0.319 | ||||
| African American | 84 (78.5) | 40 (83.3) | 44 (74.6) | ||
| Caucasian | 20 (18.7) | 8 (16.7) | 12 (20.3) | ||
| Other | 3 (2.80) | 0 (0.00) | 3 (5.08) | ||
| Vaginal delivery, n (%) | 34 (31.2) | 16 (32.7) | 18 (30.0) | 0.929 | |
| Apgar score < 6 at 5 min, n (%) | 30 (28.0) | 4 (8.33) | 26 (44.1) | <0.001 | |
| Out born, n (%) | 69 (63.3) | 28 (57.1) | 41 (68.3) | 0.314 | |
| Infant medical information prior to NEC | |||||
| Patent ductus arteriosus, n (%) | 72 (66.1) | 27 (55.1) | 45 (75.0) | 0.048 | |
| Patent ductus arteriosus, indomethacin, n (%) | 16 (15.0) | 3 (6.25) | 13 (22.0) | 0.045 | |
| Platelet transfusion before NEC, n (%) | 78 (76.5) | 36 (75.0) | 42 (77.8) | 0.923 | |
| Red blood cell transfusion before NEC, n (%) | 85 (94.4) | 39 (92.9) | 46 (95.8) | 0.661 | |
| Postoperative systemic course | |||||
| 24 h Ionotropic support, n (%) | 76 (73.1) | 30 (63.8) | 46 (80.7) | 0.088 | |
| AKI by serum creatinine, n (%) | 0.006 | ||||
| Normal | 35 (35.4) | 23 (53.5) | 12 (21.4) | ||
| Stage 1 | 23 (23.2) | 5 (11.6) | 18 (32.1) | ||
| Stage 2 | 20 (20.2) | 8 (18.6) | 12 (21.4) | ||
| Stage 3 | 21 (21.2) | 7 (16.3) | 14 (25.0) | ||
| AKI by urine output, n (%) | 0.986 | ||||
| Normal | 54 (55.1) | 23 (57.5) | 31 (53.4) | ||
| Stage 1 | 6 (6.12) | 2 (5.00) | 4 (6.90) | ||
| Stage 2 | 27 (27.6) | 11 (27.5) | 16 (27.6) | ||
| Stage 3 | 11 (11.2) | 4 (10.0) | 7 (12.1) | ||
| Central line present (days) (median [IQR]) | 60.0 [38.0;99.0] | 60.0 [43.0;87.0] | 53.5 [36.2;108] | 0.991 | |
| Positive blood culture sepsis, n (%) | 36 (33.0) | 16 (32.7) | 20 (33.3) | 0.99 | |
| CRP on day of NEC onset (median [IQR]) | 8.70 [3.20;17.7] | 12.6 [4.40;19.0] | 8.00 [2.98;17.7] | 0.575 | |
| CRP at 1 week after NEC onset (median [IQR]) | 4.60 [2.50;7.70] | 5.80 [3.00;13.4] | 4.45 [2.45;6.62] | 0.173 | |
| Hematology data | |||||
| Any packed red cell Transfusion before NEC | 85 (94.4) | 39 (92.9) | 46 (95.8) | 0.661 | |
| Hematocrit before NEC onset | 34.0 [30.2;38.2] | 34.4 [29.9;39.0] | 33.8 [30.6;37.9] | 0.655 | |
| Packed red cell Transfusion 48 before NEC | 18 (25.7) | 5 (18.5) | 13 (30.2) | 0.418 | |
| Packed red cell Transfusion 48h after NEC | 77 (78.6) | 37 (78.7) | 40 (78.4) | 1.000 | |
| Platelet transfusion before NEC | 78 (76.5) | 36 (75.0) | 42 (77.8) | 0.923 | |
| Platelet transfusion 48h after NEC | 41 (45.1) | 20 (44.4) | 21 (45.7) | 1.000 | |
| Cholestasis at NEC onset, n (%) | 61 (69.3) | 25 (69.4) | 36 (69.2) | 0.99 | |
| Length of stay (days) (median [IQR]) | 117 [72.0;171] | 138 [47.0;171] | 116 [75.8;172] | 0.951 | |
| Death, n (%) | 37 (33.9) | 21 (42.9) | 16 (26.7) | 0.116 | |