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[Preprint]. 2023 Jun 5:2023.06.01.23290850. [Version 1] doi: 10.1101/2023.06.01.23290850

Fig. 4. Association of cell-type-specific AD polygenic risk scores in A4.

Fig. 4.

a, Association of cell-type-specific ADPRSs with cortical Aβ (florbetapir PET cortical composite SUVR). b, Association of cell-type-specific ADPRSs with temporal lobe tau (flortaucipir PET temporal lobe composite SUVR). c, Association of cell-type-specific ADPRSs with hippocampal volume (HV). d, Association of cell-type-specific ADPRSs with screening Preclinical Alzheimer Cognitive Composite (PACC). y-axis indicates log10(p-value) of each association. The black solid horizontal line indicates the p-value corresponding to statistical significance (FDR=0.025), and the black dashed horizontal line indicates p=0.05. Abbreviations: SUVR, standardized uptake value ratio.