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. 2023 Jun 16;2023(6):CD012937. doi: 10.1002/14651858.CD012937.pub3

NCT03111329.

Methods RCT
Participants Infants born at 26 to 30 weeks’ gestational age and birth weight < 1500 g
Interventions No routine aspiration of prefeed gastric residuals: opening of the nasogastric tube once every 6 hours to relieve possible backflow of gastric content will be allowed
Routine monitoring of gastric residuals before each feed
Outcomes Primary outcome: 

  • time taken to achieve full enteral feeding (100 mL/kg/d)


Secondary outcomes: 

  • episodes of withholding of enteral feeding;

  • duration of TPN; 

  • duration of CVL usage;

  • hypoglycaemia;

  • late‐onset sepsis;

  • NEC; 

  • spontaneous intestinal perforation;

  • bronchopulmonary dysplasia;

  • intraventricular haemorrhage;

  • retinopathy of prematurity; and 

  • neurodevelopment at 24 months
Notes www.clinicaltrials.gov/ct2/show/NCT03111329

CVL: central venous line; NEC: necrotising enterocolitis; TPN: total parenteral nutrition; RCT: randomised controlled trial