Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul;29(7):1051–1068. doi: 10.1261/rna.079599.123

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 Miścicka et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

FIGURE 7. — Mutational analysis of domain 3/PKI. The influence of disruptive or compensatory substitutions in domain 3 of (A–G,N) the NediV IRES and (H–M,O) the APLV1 IRES on binding of ribosomes, assayed by toeprinting. Separation of lanes by white lines indicates that they were juxtaposed from the same gel. Positions of 80S:IRES complexes are indicated on the right. Summary of the effects of substitutions in (N) NediV and (O) APLV1 IRESs. Models of these IRESs are annotated to show mutations that (a) have no effect, (b) cause loss of function that is compensated by second-site mutations, and (c) impair function or lead to loss of function that is not compensated by second-site mutations, as indicated in the inset key.