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. 2023 Jun 14;8(25):22603–22612. doi: 10.1021/acsomega.3c01110

Table 1. Compounds Identified against Plpro and Mpro from the Microsource Spectrum Collection Library Screena.

compound PLpro IC50 (μM) Mpro IC50 (μM)
raloxifene 3.28 ± 0.29 42.8 ± 6.7
cetylpyridinium chloride 2.72 ± 0.09 7.25 ± 0.15
cefonicid sodium 2.17 ± 1.2  
citicoline 1.35 ± 0.27  
colistin sulfate 2.94 ± 0.54  
β-lapachone 5.30 ± 0.29  
tanshinone iia sulfonate sodium 2.76 ± 0.28  
lobaric acid 10 ± 1.11  
a

It should be noted that compounds such as β-lapachone and tanshinone may be potential false positives involved in redox cycling.18