Table 1.
Characteristics of the full participant sample and stratified by race.
| Overall Sample | Non-Latino Black Participants | Non-Latino White Participants | p-value* | |
|---|---|---|---|---|
|
| ||||
| n | 74 | 33 | 41 | |
|
| ||||
| Demographics and Covariates | ||||
|
| ||||
| Age, years | 69.19 ± 6.80 (60–89) | 69.82 ± 6.70 (61–89) | 68.68 ± 6.93 (60–85) | .479 |
| Female, % | 52.7 | 57.6 | 48.8 | .451 |
| Education, degree years | 15.64 ± 2.59 (10–22) | 15.12 ± 2.55 (10–18) | 16.05 ± 2.59 (12–22) | .127 |
| pVIQ derived from WTAR word reading | 108.54 ± 11.15 (79–126) | 100.33 ± 6.58 (89–110) | 115.15 ± 9.60 (79–126) | <.001 |
| HAM-D (n=66) | 1.05 ± 1.41 (0–7) | 1.00 ± 1.75 (0–7) | 1.08 ± 1.13 (0–4) | .829 |
| Mini Mental State Examination | 28.95 ± 1.27 (25–30) | 28.85 ± 1.30 (26–30) | 29.02 ± 1.26 (25–30) | .557 |
| FSRP-10§ | 6.68 ± 5.20 (1.08–26.28) | 7.63 ± 5.69 (2.51–26.28) | 5.92 ± 4.69 (1.08–17.49) | .040 |
| BMI | 29.24 ± 6.27 (18.74–46.11) | 30.21 ± 6.27 (19.86–46.11) | 28.46 ± 6.23 (18.74–45.96) | .235 |
| WMH Volume, mm3§ | 3759.21 ± 4756.53 (224.88 – 21205.40) |
3739.36 ± 4184.88 (265.32–18937.13) | 3775.19 ± 5222.89 (224.88–21205.40) | .403 |
| ICV, mm3 | 1511034.54 ± 175291.57 (1120609.42 – 1904676.26) |
1470569.49 ± 152757.83 (1120609.42–1764418.87) | 1543603.96 ± 187005.08 (1168488.28–1904676.26) | .075 |
|
| ||||
| Inflammatory Markers | ||||
|
| ||||
| IL-6, pg/mL§ | 3.97 ± 2.42 (0.87–10.33) | 4.29 ± 2.23 (0.87–9.85) | 3.71 ± 2.56 (0.91–10.33) | .149 |
| CRP, pg/mL | 3.07 ± 1.72 (0.23–6.02) | 3.38 ± 1.79 (0.23–6.02) | 2.83 ± 1.65 (0.24–6.02) | .170 |
| IL-1β , pg/mL (n=65) | 0.57 ± 0.12 (0.49–1.45) | 0.56 ± 0.05 (0.50–0.68) | 0.58 ± 0.15 (0.49–1.45) | .819 |
*
p-values for comparisons by race.
§
Raw values reported in Table 1 for ease of interpretation; log-transformed values used in analyses. Values are mean ± standard deviation (range) unless otherwise stated. pVIQ = predicted verbal intelligence quotient derived from WTAR=Wechsler Test of Adult Reading; HAM-D=Hamilton Depression Rating Scale score; FSRP-10=Framingham Stroke Risk Profile 10-year percent risk of stroke; BMI=body mass index; WMH=white matter hyperintensity; mm3=millimeters cubed; ICV=intracranial volume; IL-6=interleukin-6; CRP=C-reactive protein; IL-1β=interleukin 1-beta; pg/mL=picograms per milliliter.