Table 3.
Significant interactions between inflammatory markers and race on efficiency in a priori regions of interest in the full sample.
| Region of Interest | β (SE) | t-value | p-value | partial η2 |
|---|---|---|---|---|
|
| ||||
| CRP | ||||
| Amygdala | ||||
| FSRP-10 | −1.097 (.792) | −1.384 | .171 | .029 |
| BMI | −.062 (.039) | −1.586 | .118 | .037 |
| pVIQ | −.012 (.027) | −.433 | .667 | .003 |
| WMH | .454 (.547) | .831 | .409 | .011 |
| ICV | −1.04E−6 (1.32E−6) | −.784 | .436 | .009 |
| Race | −.941 (1.055) | −.892 | .376 | .012 |
| CRP | −.413 (.192) | −2.153 | .035 | .067 |
| CRP*Race Interaction | .532 (.264) | 2.014 | .048 | .059 |
| Thalamus | ||||
| FSRP-10 | −.047 (.200) | −.234 | .816 | .001 |
| BMI | −.021 (.010) | −2.106 | .039 | .064 |
| pVIQ | −.010 (.007) | −1.441 | .154 | .031 |
| WMH | .120 (.138) | .866 | .390 | .011 |
| ICV | −4.87E−8 (3.35E−7) | .145 | .885 | <.001 |
| Race | −.494 (.267) | −1.851 | .069 | .050 |
| CRP | −.060 (.049) | −1.227 | .224 | .023 |
| CRP*Race Interaction | .138 (.067) | 2.059 | .044 | .061 |
|
| ||||
| IL-6 | ||||
|
| ||||
| Amygdala | ||||
| FSRP-10 | −1.174 (.784) | −1.497 | .139 | .033 |
| BMI | −.082 (.038) | −2.156 | .035 | .067 |
| pVIQ | −.009 (.027) | −.333 | .740 | .002 |
| WMH | .476 (.537) | .887 | .379 | .012 |
| ICV | −6.07E−7 (1.31E−6) | −.463 | .645 | .003 |
| Race | −1.371 (1.074) | −1.276 | .207 | .024 |
| IL-6 | −1.889 (1.045) | −1.807 | .075 | .048 |
| IL-6*Race Interaction | 4.030 (1.671) | 2.412 | .019 | .082 |
| Pars Triangularis | ||||
| FSRP-10 | .004 (.393) | .011 | .992 | <.001 |
| BMI | −.035 (.019) | −1.852 | .068 | .050 |
| pVIQ | −.010 (.014) | −.719 | .475 | .008 |
| WMH | .649 (.269) | 2.411 | .019 | .082 |
| ICV | −7.66E−7 (6.57E−7) | −1.166 | .248 | .020 |
| Race | −1.445 (.538) | −2.685 | .009 | .100 |
| IL-6 | −.400 (.524) | −.763 | .448 | .009 |
| IL-6*Race Interaction | 1.929 (.837) | 2.304 | .024 | .076 |
| Superior Frontal Gyrus | ||||
| FSRP-10 | −.028 (.224) | −.126 | .900 | <.001 |
| BMI | −.018 (.011) | −1.641 | .016 | .040 |
| pVIQ | −.009 (.008) | −1.138 | .259 | .020 |
| WMH | .205 (.153) | 1.337 | .186 | .027 |
| ICV | −5.923E−7 (3.740E−7) | −1.584 | .118 | .037 |
| Race | −.470 (.306) | −1.534 | .130 | .035 |
| IL-6 | −.528 (.298) | −1.773 | .081 | .046 |
| IL-6*Race Interaction | .995 (.476) | 2.089 | .041 | .063 |
|
| ||||
| IL-1β | NS | NS | NS | NS |
Note: Entries reflect full linear regression model interaction results for the interaction of inflammatory markers and race on efficiency. FSRP-10, WMH, and IL-6 were log-transformed for data normalization. Efficiency metrics were multiplied by a factor of 1000 for ease of interpretation. pVIQ = predicted verbal intelligence quotient derived from the Wechsler Test of Adult Reading; HAM-D=Hamilton Depression Rating Scale score; FSRP-10=Framingham Stroke Risk Profile 10-year percent risk of stroke; BMI=body mass index; WMH=white matter hyperintensity; ICV=intracranial volume; IL-6 = Interleukin-6; CRP = C-Reactive Protein; IL-1β = Interleukin 1-beta; NS = not significant.