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. 2023 Jun 8;3(6):688–704. doi: 10.1038/s43587-023-00431-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Dot plot showing percentage of cells expressing and average expression of IL-17 receptors Il17ra and Il17rc, and ligands Il17a and Il17f in all dermal cell types. Black boxes enclose lymphoid subtypes that show differential expression of Il17a and Il17f upon aging. b, Fluorescent in situ hybridization (FISH) for IL17A (n = 4 individual donors for adult and n = 3 individual donors for aged) and IL17F (n = 4 individual donors for each age) in adult and aged human skin (top panel). Bar = 50μm. White arrows point to positive cells. Insets with higher magnification focusing on the dermis in the bottom panel, bar = 10μm. Plot shows quantification in percentage of positive cells. Brightness and contrast were adjusted only for visualization purposes. Quantifications were done in raw images.