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. 2023 May 22;3(6):722–733. doi: 10.1038/s43587-023-00421-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Volcano plot of differentially expressed genes in nasal mucosa of fatal (n = 20) versus age-matched, sex-matched and outbreak-matched non-fatal PCR-positive cases (n = 30), quantified by nCounter digital transcriptomics (uncorrected P values from linear model, negative binomial distribution, dotted line showing P < 0.05, FDR q values provided in Source Data). Selected viral (red circles) and host immune transcripts (blue circles) significantly upregulated or downregulated in fatal versus non-fatal cases are highlighted with gene names. Details on immune genes are given in the Results section. PCR+, PCR positive.

Source data