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. 2023 May 9;42(25):2074–2087. doi: 10.1038/s41388-023-02703-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Messenger RNA collected from KPV^+/+ and KPV^−/− cells was subjected to RNA sequencing. A Differentially expressed genes (DEGs) between KPV^+/+ and KPV^−/− cells were clustered using K-means clustering. B Genes enriched in Cluster 1 (316 genes) and Cluster 2 (588 genes) were subjected to GO enrichment analysis. GO Processes with FDR < 0.05 are shown. GeneRatio is the number of genes in the cluster associated with the GO process divided by the total number of genes in that GO process. C Expression values (counts per million; CPM) of select genes are shown. N = 3 for each group. Data in panel C are presented as the mean ± standard deviation. All gene comparisons (KPV^+/+ vs. KPV^−/−) have FDR < 0.05 after adjusting for multiple comparisons; therefore, all gene differences shown between KPV^+/+ vs. KPV^−/− cells are statistically significant.