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. 2023 Jun 16;14:104. doi: 10.1007/s12672-023-00702-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Structure and function of syncytin-1. A The general structure of HERV consists mainly of two identical LTR sequences and four typical viral genes, gag, pro, pol and env. And there is a transcriptional promoter at the end of the 5'LTR. The structure of syncytin-1 and syncytin-2 mainly includes SU domains and TM domains. B Syncytin-1 could promote the fusion of somatic cells and cancer cells