Table 1.
Epitope | Scaffold | Sequence | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | TATA | A | Ci | E | Y | V | G | P | M | Cii | Y | R | L | Y | Ciii | A | ||
A | Ci | E | Y | x | G | P | x | Cii | x | R | L | Y | Ciii | A | ||||
2 | TATA | A | Ci | P | Y | V | A | G | R | G | T | Cii | L | L | Ciii | A | ||
A | Ci | P | x | x | x | G | x | G | x | Cii | L | L | Ciii | A | ||||
2b | TATA | A | Ci | M | F | V | P | Cii | A | V | R | H | A | L | G | L | Ciii | A |
A | Ci | M | x | x | P | Cii | x | x | R | x | x | L | G | L | Ciii | A | ||
3 | TATA | A | Ci | E | D | N | D | W | V | Y | Cii | S | T | Ciii | A | |||
A | Ci | x | x | x | x | W | x | Y | Cii | S | T | Ciii | A | |||||
4 | TATB | A | Ci | I | P | L | D | W | T | Cii | M | I | A | Ciii | A | |||
A | Ci | x | x | x | D | W | T | Cii | x | x | x | Ciii | A | |||||
5 | TATB | A | Ci | A | N | P | D | N | P | V | Cii | R | F | Y | Ciii | A | ||
A | Ci | x | N | x | x | N | P | V | Cii | R | F | Y | Ciii | A | ||||
6 | TATB | A | Ci | D | H | Y | H | Cii | P | W | L | A | L | G | G | S | Ciii | A |
7 | TATB | A | Ci | I | N | P | Y | Cii | E | H | H | I | Y | L | E | H | Ciii | A |
9 | TATB | A | Ci | M | N | P | F | F | Y | D | Cii | E | T | V | Ciii | A | ||
A | Ci | M | N | P | F | x | x | x | Cii | x | x | x | Ciii | A | ||||
11 | TCMT | A | Ci | F | P | E | P | W | L | G | L | Cii | T | P | Ciii | A | ||
A | Ci | F | P | x | P | W | L | G | L | Cii | T | P | Ciii | A | ||||
12 | TATA | A | Ci | S | S | K | F | Cii | D | A | W | W | N | F | N | R | Ciii | A |
A | Ci | S | x | x | F | Cii | x | A | W | x | x | F | N | x | Ciii | A |
The sequences of example peptides for each epitope group is shown together with the scaffold. Full name of scaffolds: TATA is 1,1’,1”-(1,3,5-triazinane-1,3,5-triyl)triprop-2-en-1-one, also known as triacryloylhexahydro-s-triazine; TATB is 1,3,5-tris(bromoacetyl) hexahydro-1,3,5-triazine; TCMT is 2,4,6-tris(chloromomethyl)-s-triazine.