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. 2023 Jun 16;14:3584. doi: 10.1038/s41467-023-39069-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Maximum intensity projections (MIPs) along the z (dorsal view) and y (coronal view) directions of the LOT images acquired in vivo from three mice affected by ischemic stroke. A anterior, P posterior, M medial, L lateral, I ipsi-lateral, C contra-lateral. Scalebar—4 mm, a.u. arbitrary units. b Dorsal and coronal MIPs of the corresponding velocity maps. c Dorsal and coronal MIPs of the corresponding bio-distributions of oxygenated (red) and deoxygenated (blue) hemoglobin, a.u. arbitrary units. Oxygen saturation (sO₂) values in the microvascular structures resolved with LOT are superimposed. d Statistical analysis of the measured parameters in selected volumes of interest (VOIs, orange and green regions indicated in a) in ipsi-lateral and contra-lateral sides of the brain. The number of mice (n) considered are indicated. Individual measurements are plotted as blue circles. First row—Relative number of localized points in ipsi- (27.27% +/− 11.90%) and contra-lateral (72.73% +/− 11.90%) sides. Second row—Relative number of vertical vessels in ipsi- (29.72% +/− 12.99%) and contra-lateral (70.28% +/− 12.99%) sides estimated as the relative L1-norm of the Sobel-filtered LOT image for the selected VOIs. Third row—Blood flow velocities in the visible vessels in the ipsi- (16.05 mm/s +/− 1.31 mm/s) and contra-lateral sides (19.97 mm/s +/− 1.58 mm/s). Fourth row—Oxygen saturation in the visible vessels in the ipsi- (0.3087 + /− 0.0594) and contra-lateral (0.5453 + /− 0.0293) sides. Data are presented as mean values +/− standard deviation. Statistical significance is shown (*0.01 < p < 0.05, ***p < 0.001 for a two-tailed paired-sample t test).