Table 3.
Group classification performance with separate metrics and with multimodal metrics for the cross-sectional data.
| All ALS participants vs. controls | Low UMN score (< 3) ALS participants vs. controls | |||||
|---|---|---|---|---|---|---|
| Measure | Accuracy (%) | Sensitivity (%) | Specificity (%) | Accuracy (%) | Sensitivity (%) | Specificity (%) |
| Brain FA | 82.5 | 80.0 | 85.0 | 75.9 | 69.2 | 85.0 |
| Brain Fsum | 72.5 | 70.0 | 75.0 | 67.0 | 61.5 | 80.0 |
| Precentral cortical thickness | 72.5 | 70.0 | 75.0 | 67.0 | 46.2 | 90.0 |
| Spinal cord CST FA at C2 | 60.0 | 55.0 | 65.0 | 62.1 | 46.2 | 80.0 |
| Spinal cord CSA at C2 | 72.5 | 65.0 | 80.0 | 75.9 | 69.2 | 85.0 |
| Multimodal* | 87.5 | 90.0 | 85.0 | 93.1 | 92.3 | 95.0 |
*Multimodal analysis, which provided the best accuracy and sensitivity, included brain FA, cortical thickness, cord CST FA at C2, and cord CSA at C2 (ALS Amyotrophic lateral sclerosis, FA Fractional anisotropy, Fsum Sum of fiber volume fractions, CST Corticospinal tract, C2 Spinal cord C2 level, CSA Cross-sectional area, UMN Upper motor neuron).