Table 4.

Effect size and p-values in ALS participants: Multimodal longitudinal 12-month change data.

Measure	Effect size (standardized response mean)	P-value: paired t-test for longitudinal change	Corrected p-value (Bonferroni-Holm)
Brain FA	0.89	0.014*	0.056
Brain Fsum	1.00	0.0078*	0.039*
Superior temporal cortical thickness	0.85	0.018*	0.054
Spinal cord RD CST at C2	0.75	0.033*	0.066
Spinal cord CSA CST at C2	0.13	0.680	0.680
Brain FDC	1.33	0.0013*	0.0078*
Brain FC	1.34	0.0012*	0.0084*
Brain FD	1.41	0.0008*	0.0070*

Mean FA and Fsum are for voxels with significant change in the TBSS analysis. See text for explanation.

^*p-value < 0.05 (ALS Amyotrophic lateral sclerosis, FA Fractional anisotropy, Fsum Sum of fiber volume fractions, CST Corticospinal tract, C2 Spinal cord C2 level, CSA Cross-sectional area, RD Radial diffusivity, FDC Fiber density and cross-section).