Table 2.
Activity of the cyanomethyl vinyl ethers derivatives against epimastigote stage of Trypanosoma cruzi, represented as inhibitory concentration 50 (IC50 in μM). BENZ: benznidazole.
| ID | IC50 (μM) | ID | IC50 (μM) | ID | IC50 (μM) |
|---|---|---|---|---|---|
| E51 | 39.96 ± 3.73 | E67 | >150 | E83 | 11.25 ± 1.47 |
| E52 | 50.09 ± 0.28 | E68 | >150 | E84 | 67.6 ± 1.35 |
| E53 | 8.84 ± 0.37 | E69 | >150 | E85 | >150 |
| E54 | 13.4 ± 1.24 | E70 | >150 | E86 | >150 |
| E55 | 36.24 ± 0.65 | E71 | >150 | E87 | >150 |
| E56 | 49.1 ± 2.79 | E72 | >150 | E88 | >150 |
| E57 | >150 | E73 | 38.48 ± 3.51 | E89 | >150 |
| E58 | >150 | E74 | 8.88 ± 0.95 | E90 | >150 |
| E59 | >150 | E75 | 10.1 ± 1.74 | E91 | >150 |
| E60 | >150 | E76 | 10.27 ± 1.64 | E92 | >150 |
| E61 | >150 | E77 | >150 | E93 | >150 |
| E62 | >150 | E78 | >150 | E94 | >150 |
| E63 | 5.43 ± 0.14 | E79 | >150 | E95 | >150 |
| E64 | 8.91 ± 1.75 | E80 | >150 | E96 | >150 |
| E65 | 47.77 ± 1.3 | E81 | >150 | ||
| E66 | 46.62 ± 5.21 | E82 | >150 | BENZ | 6.92 ± 0.77 |