Table 3.
Cytotoxicity of the cyanomethyl vinyl ethers derivatives against murine macrophages, represented as cytotoxic concentration 50 (CC50 in μM). ND: not determined. BENZ: benznidazole.
| ID | CC50 (μM) | ID | CC50 (μM) | ID | CC50 (μM) |
|---|---|---|---|---|---|
| E51 | 709.44 ± 20.48 | E67 | ND | E83 | 339.82 ± 6.36 |
| E52 | >700 | E68 | ND | E84 | >300 |
| E53 | 47.47 ± 52.24 | E69 | ND | E85 | ND |
| E54 | 200.46 ± 6.04 | E70 | ND | E86 | ND |
| E55 | >700 | E71 | ND | E87 | ND |
| E56 | >700 | E72 | ND | E88 | ND |
| E57 | ND | E73 | >300 | E89 | ND |
| E58 | ND | E74 | >1300 | E90 | ND |
| E59 | ND | E75 | 96.76 ± 23.36 | E91 | ND |
| E60 | ND | E76 | 157.98 ± 18.99 | E92 | ND |
| E61 | ND | E77 | ND | E93 | ND |
| E62 | ND | E78 | ND | E94 | ND |
| E63 | 167.13 ± 4.13 | E79 | ND | E95 | ND |
| E64 | >300 | E80 | ND | E96 | ND |
| E65 | >700 | E81 | ND | ||
| E66 | >700 | E82 | ND | BENZ | 399.91 ± 1.4 μM |