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. 2023 Feb 25;43(5):951–964. doi: 10.1007/s10875-022-01426-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Patient 2: metabolic detoxification and lymphocyte levels throughout the study. Values obtained at Screening are indicated by a shaded gray box. Cut-off values for meeting full metabolic detoxification are indicated in the top panel by the horizontal dashed lines, colored to match the corresponding data set. Screening values were obtained while patients were on pegademase and may not be trough values