FIGURE 2.

CCT is required for the maintenance of lipid profile in cells. (a) Heatmap of lipid abundance in siCtrl and siCCT cells. The figure shows the clustering results in the form of a dendrogram. Values are measured by Euclidean distance with a Ward clustering algorithm (n = 5 per group); cells used for this study were Jurkat E6‐1. 1–5: sample number. (b) Scheme of lipids differently present in siCCT cells, which are related to EVs biogenesis or structure. Arrows show the increase (red) or decrease (blue) of the lipid amount in the cell. Cer, ceramide; DG, diacylglycerol; MG, monoacylglycerol; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PG, phosphatidylglycerol; TG, triacylglycerol; SM, sphingomyelin.