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. Author manuscript; available in PMC: 2023 Jun 17.
Published in final edited form as: Sci Transl Med. 2022 Oct 5;14(665):eabn2956. doi: 10.1126/scitranslmed.abn2956

Fig. 1. Seizures, oscillation periodicity, and meal effect in G1D.

Fig. 1.

(A) Electroencephalographic recordings illustrating four seizures in one G1D individual at various times of the day. The seizures occurred at the following times (from top to bottom): 2:24:50 p.m., 5:31:34 p.m., 3:50:36 a.m., and 8:44:05 a.m. The oscillatory period was invariant. (B) Four seizures recorded from an individual with the unrelated epileptic disorder electrical status epilepticus in sleep. These seizures occurred (from top to bottom) at 12:05:49 p.m., 12:22:02 p.m., 12:22:14 p.m., and 12:05:55 p.m. and displayed spontaneously variable oscillatory frequency. (C) Effect of seven meals on number of seizures recorded from three G1D individuals. Pre- and post-meal comparison *P < 0.05, paired t test. (D) Effect (paired t test) of meals on seizure duration in the same individuals. Ranges, SEM. (E). Representative pre-meal (black trace) and post-meal (red trace) seizure in an individual from (A) illustrating similar oscillation period.