Analysis of donor-derived genome edited chimerism
(A) Gating strategy for analyzing peripheral blood cell chimerism.
(B) Donor-derived chimerism in the primary transplantation 10 days after genome editing (n = 6–10 from two independent transplantations) HSCs in quiescence-maintaining culture (black), GFP-edited HSCs in quiescence-maintaining culture (blue), and GFP-edited HSCs in proliferative culture (red). The Turkey–Kramer multiple comparisons test was used. ∗∗∗p < 0.001.