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. Author manuscript; available in PMC: 2023 Jun 17.
Published in final edited form as: Prog Retin Eye Res. 2019 Sep 4;75:100777. doi: 10.1016/j.preteyeres.2019.100777

Figure 10. Comparison of MUC1, MUC4, and MUC16 Localization at the Human and Mouse Ocular Surface.

Figure 10.

The graphics compare the corneal epithelium (top) and conjunctiva (bottom) from human (left) and mouse (right). As depicted, the corneal epithelium in mouse has more cell layers than human; the human corneal stroma is thicker than that of mouse.

The expanded insets depict a single apical epithelia cell from the corneal or conjunctival epithelium of mouse or human, showing the surface microplicae. With the EDs of MAMs MUC1, MUC4, and MUC16 projecting outward into the tear film. The EDs of the two longest MAMs, MUC16 and MUC4, are substantially shorter in mouse than human. MUC4 appears to substitute for MUC16 on the corneal epithelium of mouse, which further reduces the overall length of MAM EDs on the corneal epithelium.

MUC1: orange; MUC4: blue; MUC16: green.