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. Author manuscript; available in PMC: 2023 Jun 17.
Published in final edited form as: Prog Retin Eye Res. 2019 Sep 4;75:100777. doi: 10.1016/j.preteyeres.2019.100777

Figure 6. Modular Architecture of Ocular Surface Membrane Associated Mucins (MAMs).

Figure 6.

Shown are the extended conformations of MAM proteins prior to intracellular processing, but with the final relationship to the plasma membrane depicted. The extracellular domain of each protein is to the left of the plasma membrane. MAMs could not be drawn to scale because of extreme size differences, but an effort was made to depict relative differences in overall size, and relative location and sizes of the modular units. The signal peptides are located at the amino-terminus of each protein. The approximate intracellular cleavage sites of each mucin are indicated by scissors. MUC20 has been experimentally determined to associate with the plasma membrane, but no transmembrane domain has been identified.

SP: signal peptide; TM: transmembrane domain; VNTR: Variable Number Tandem Repeats; conserved modular domains as in Table 3. GSLV: proposed cleavage site for MUC21.