Table 3:

Conserved Motifs Found in Human MAMs Expressed at the Ocular Surface

Motif	Definition	MAMs with the Motif
SEA	Sperm protein, Enterokinase and Agrin module. Regulates or binds carbohydrate side chains	MUC1, MUC13, MUC16, MUC17
KdpC	K+-transporting ATPase, c chain module; interacts with KdpA subunit to assemble and stabilize the Kdp complex	MUC1
AMOP	Adhesion-associated domain	MUC4
NIDO	Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins	MUC4
VWD	Von Willebrand factor type D domain	MUC4
EGF-like	Cysteine-rich EGF-like modules	MUC3, MUC4, MUC12, MUC13, MUC17
PHA03247	Large tegument protein UL36, found in Herpes simplex virus, provisional	MUC20
Epiglycanin_TR	Tandem-repeating region of mucin, epiglycanin-like	MUC21
Epiglycanin_C	Non-tandem repeat portion of ED, including cleavage site, transmembrane domain and CT	MUC21, MUC22

All except the EGF-like motif are identified in the individual gene profiles in the NCBI Gene database